Dr. Guoyun Chen, Assistant Professor

Dr. Chen received his Bachelor of Medicine (1995) and Master’s Degree in Biochemistry (1998) from JiangXi Medical College in China. Following completion of his Master’s Degree, he attended Nagoya University in Japan where he obtained a PhD in Physiology (2002).

Dr. Chen worked as a Researcher in the Core Research for Evolutional Science and Technology at the Aichi Cancer Center in Japan prior to joining Dr. Yang Liu’s laboratory at the University of Michigan in 2007. He was promoted to Research Investigator at the University of Michigan (2009) and to Assistant Professor at Children’s National Medical Center (2012). During this time, he identified a novel pathway, which could distinguish between danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) (Science, 2009). Further studies showed that this discrimination is sialoside-based pattern recognition. These observations led to a new concept that sialoside-based pattern recognition may play a fundamental role in discrimination of infectious nonself from noninfectious self (Nature Biotechnology, 2011). 

Dr. Chen’s laboratory is currently interested in dissecting the molecular and cellular mechanisms associated with the development of sepsis. He is taking molecular, cellular and genetic approaches to elucidate these mechanisms with the goal of developing novel therapeutic approaches for septic shock and improving outcomes of patients with severe sepsis. Currently he is conducting research projects under the mentorship of Dr. Samir Shah.

Selected Publications

  1. Wu Y, Ren D, and Chen GY. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol 1600772; published ahead of print September 12, 2016,doi:10.4049/jimmunol.1600772.
  2. Wu Y, Lan C, Ren D, Chen GY. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-β1 Production.
    J Biol Chem. 2016 Jun 3;291(23):12370-82. doi: 10.1074/jbc.M116.721258. Epub 2016 Apr 18.
  3. 29(5):406–407; Research Highlight: Nature Reviews Drug Discovery 2011 June, 10:416.).
  4. Sakuma K, Chen GY, Aoki M, and Kannagi R. Induction of 6-sulfated Glycans with Cell Adhesion Activity via T-bet and GATA-3 in Human Helper T Cells. Biochimica et Biophysica Acta, 2012 Jul. 1820(7):841-8.
  5. Shi X, Chen GY, et al. Characterization of Glycyrrhizic Acid as a Broad Hepatoprotective  Agent Against Divergent Liver Diseases. Science Translational Medicine, submitted.
  6. Chen GY, Brown NK, Wu W, Khedri Z,Yu H, Chen X, Vlekkert DV, D’Azzo A, Zheng P, Liu Y. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. Elife. 2014 Sep 3:e04066. doi: 10.7554/eLife.04066. [Epub ahead of print], Corresponding author.
  7. Chen GY, Brown NK, Zheng P, Liu Y. Siglec G/10 in self-Nonself Discrimination of Innate and Adaptive Immunity. Glycobiology. 2014 Sep;24(9):800-6. doi: 10.1093/glycob/cwu068. Epub 2014 Jul 4, Corresponding author, invited Review.
  8. Wang L, Liu R, Ye P, Wong C, Chen GY, Zhou P, Sakabe K, Zheng X, Wu W5, Zhang P, Jiang T, Bassetti MF, Jube S, Sun Y, Zhang Y, Zheng P, Liu Y. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20;6:5909. doi: 10.1038/ncomms6909.

Dr. Mark Bugnitz photo

Email: gchen@uthsc.edu
Phone: (901) 287-6883

Contact Us

Department of Pediatrics

Critical Care Division

Le Bonheur Children's Hospital
Children's Foundation
Research Center
50 N Dunlap, 3rd Floor
Memphis, TN 38103
Phone: 901-287-6303