Dr. Alina Nico West

Instructor

Dr. West graduated from the University of Tennessee Health Sciences Center College of Medicine in 2013 and completed her PhD training in the Interdisciplinary Sciences through the University of Tennessee Health Sciences Center College of Graduate Health Sciences (2007) in the laboratory of Dr. Gerard Zambetti at St. Jude Children's Research Hospital. She studied aspects of the etiology of pediatric adrenocortical tumors through an NIH-funded program project supporting the St. Jude Children's Research Hospital International Pediatric Adrenal Cortical Tumor Registry (IPACTR). Her research included identification and characterization of novel germline p53 tumor suppressor mutations in pediatric adrenocortical tumors (Cancer Research, 2006; Journal of Medical Genetics, 2008) and aberrant gene expression in a pediatric adrenocortical tumor cohort (Cancer Research, 2007).

Dr. West completed her postdoctoral training at the University of Tennessee Health Sciences Center in the Department of Physiology under the mentorship of Drs. Christopher Waters and Andreas Schwingshackl. She contributed to research focused on expression of novel ion channels in hyperoxia models in vitro (AJP Lung Cellular and Molecular Physiology, 2012) and in vivo.

Dr. West primarily has an interest in Neurocritical Care Research and is developing her own research program focusing on biomarkers of neural re-connectivity following pediatric severe traumatic brain injury. She has formed research partnerships within the Division of Pediatric Critical Care Medicine, as she is Co-Investigator on several new and existing clinical and translational research studies. She has also formed a research partnership with the LeBonheur Center for Health Equity.

Publications

  1. Shah S, Shah N, Johnson R, West AN, Prasad N (2016). Single Center Outcomes of Status Epilepticus at a Paediatric Intensive Care Unit. Can J Neurol Sci 43(1): 105-12.
  2. Shah SH, West AN, Sepanski RJ, et al. (2015). Clinical Risk Factors For Central Line Associated Venous Thrombosis (CLAVT) In Children. Front. Pediatr May 5 3:35.
  3. Schwingshackl A, Teng B, Ghosh M, et al. (2012). Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 302(1): L93-L102.
  4. Russell-Swetek A, West AN, Mintern JE, et al. (2008). Identification of a novel TP53 germline mutation E285V in a rare case of paediatric adrenocortical carcinoma and choroid plexus carcinoma. Journal of Medical Genetics 45(9): 603-6.
  5. Doghman M, Arhatte M, Thibout H, et al. (2007). Nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor/nephromblastoma overexpressed gene-3 (NOV/CCN3), a selective adrenocortical cell proapoptotic factor, is down-regulated in childhood adrenocortical tumors. Journal of Clinical Endocrinology and Metabolism, 92(8): 3253-60.
  6. Broniscer A, Baker SJ, West AN, et al. (2007). Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. Journal of Clinical Oncology, 25(6): 682-9.
  7. West AN, Neale GA, Pounds S, et al. (2007). Gene expression profiling of childhood adrenocortical tumors. Cancer Research, 67(2): 600-8.
  8. Ribeiro RC, Rodriguez-Galindo C, Figueiredo BC, et al. (2007). Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome. Cancer Letters, 247(2): 353-5.
  9. West AN, Ribeiro RC, Jenkins J, et al. (2006). Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma. Cancer Research, 66(10): 5056-62.

Dr West profile photo

Email: awest3@uthsc.edu
Phone: (901) 287-5308

Contact Us

Department of Pediatrics

Critical Care Division

Le Bonheur Children's Hospital
Children's Foundation
Research Center
50 N Dunlap, 3rd Floor
Memphis, TN 38103
Phone: 901-287-6303