Research Faculty

Karen Hasty

Karen Hasty, PhD
, holds the George Thomas Wilhelm Endowed Professorship in Orthopaedic Surgery within the UT-Campbell Clinic Department of Orthopaedic Surgery and Biomedical Engineering and is Director of Basic Research in the Department. Her research is currently funded by grants from the Arthritis Foundation, the Veteran's Administration, and the National Institutes of Health. Dr. Hasty completed her doctorate in Anatomy (1981) studying cartilage regeneration with an Arthritis Foundation fellowship (1985) at the University of Tennessee Health Science Center working on the matrix metalloproteinases involved in joint destruction. Her current research focuses on early diagnosis and treatment of cartilage damage in arthritis using theragnostic nanosomes localizing to damaged cartilage in small animal models and the pathways that function for induction of osteoarthritis with biomechanical stress. In addition, her interests also lie in tissue engineering for clinical orthopaedic applications. A Career Scientist at the VA, Dr. Hasty has been a reviewer for the Journal of Cellular Physiology; Journal of Clinical Investigation; Arthritis and Rheumatism, Journal of Immunology; Journal of Biological Chemistry; Journal of Cell Biology; Matrix; Histochemical Journal and Cartilage and Osteoarthritis for 16 years. She has published more than 82 journal articles, has presented more than 115 abstracts and has written segments in seven books.
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Hongsik Jake Cho, Ph.D, MBA
, is an Assistant Professor in Department of Orthopaedic Surgery and Biomedical Engineering within the University of Tennessee-Campbell Clinic in Memphis. His research is currently funded by grants from the Arthritis Foundation and the Veteran's Administration, respectively. Dr. Cho completed his doctorate in biomedical engineering (2003) at the Ajou University in Korea, a post-doctoral trainee (2006) at the University of Tennessee Health Science Center and MBA at Georgia Institute of Technology (2009). He is an associate member of the Orthopaedic Research Society (ORS) and Korean Tissue Engineering and Regenerative Medicine Society (KTERMS). Dr. Cho has experience culturing human primary cells and adipose-derived stem cells (ADSC) for the transplantation of autologous chondrocytes, using tissue-engineering techniques to rebuild cartilage and disc tissue, investigating the effects of sonication on osteoarthritis cartilage, nanotechnology with immuno-liposome and studying the effects of cytokines on arthritis induced cartilage and disc tissue.

Dr. Cho’s long-term goals include developing and commercialize better treatments that can be directly applied in the clinical setting of biomedical and orthopedic healthcare. Instead of doing research that is theoretical and does not provide immediate assistance to patients with osteoarthritis, his goals are to focus his research on creating therapeutic products that can immediately be placed into treatment protocols.

Weikuan Gu,

Weikuan Gu, PhD
joined the University in 2002. He obtained his PhD in 1994 from Cornell University and completed postdoctoral studies in 1996. Dr. Gu has published 63 peer reviewed publications, eight book chapters, and 43 abstracts/presentations. Dr. Gu recently edited a book named "Gene Discovery for Disease Models" which has been published by Wiley. His research currently focuses on two areas: (a) positional cloning and functional studies of spontaneous mutations of genes in mice using a newly developed integrative strategy, which combines genomic resources and updated biotechnologies, and (b) identification of genetic factors that regulate bone density, bone structure, and susceptibility to arthritis. For characterization of genes involved with bone metabolism, our researchers are using the nanoindentation technology and genetic markers to map the quantitative trait loci (QTL) of bone quality from a mouse F2 population. In arthritis research, he is using the QTL mapping and microarray technology to identify pathways that regulate resistance to the spontaneous arthritis in IL-1ra deficient mice (funded by NIH, collaborating with Dr. J. Stuart at VA Medical Center and Dr. K. Hasty). In addition, he is Director for the DNA Discovery Core of the UTHSC Center of Genomics and Bioinformatics. The core, which services the UT research and education community, has the capacity of high throughput gene expression analysis, genotyping, and mutation/polymorphism screening. Learn more at the Gene Discovery Labexternal link website.

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Susan A. Miranda, PhD joined the University in 2014. She obtained her Ph.D. in molecular biology from UCLA in 2004 and completed her postdoctoral fellowship at Dana-Farber Cancer Institute in 2008.

The goal of the Miranda Lab is to understand the mechanism of action of estrogens in bone cells, especially focusing on the genes regulated by estrogens in osteoblasts and osteoclasts. Understanding the molecular biology of estrogens in bone is critical to preventing and/or treating osteoporosis. Osteoporosis is a significant public health concern that affects over 10 million people in the United States. Estrogens are important in the development of bone and maintenance of bone mineral density in both men and women. It has been known for a long time that estrogens are necessary for strong bones, but little is known about their mechanism of action in bone cells.

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Department of
Orthopaedic Surgery and Biomedical Engineering

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Memphis, TN 38104

Pat Goedecke
Phone: (901) 448-5879
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Rosemary Graham
Education Coordinator
Phone: (901) 759-3274