Victor V. Chizhikov, Ph.D.

Victor V. Chizhikov, Ph.D.

Assistant Professor
Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center


The University of Tennessee Health Science Center
855 Monroe Ave, Link Building, Ste 515
Memphis, TN 38163
Phone: (901) 448-2309
Fax: (901) 448-7193
Lab: 528 Johnson Building
Email: Victor V. Chizhikov



Education

  • Ph.D. Institution: NN Blokhin Cancer Research Center, Moscow, Russia
  • Postdoctoral: University of Chicago, Department of Human Genetics, Chicago, IL

Research Interests

Our laboratory has two goals: (1) to identify the molecular mechanisms that regulate the development of the mammalian brain and (2) to define the pathogenic mechanisms that underlie human developmental brain disorders. Specifically, we focus on two dorsal brain regions - the developing cerebellum and the cerebral cortex. The cerebellum is a major center of motor-coordination and is also involved in certain cognitive functions. The cerebral cortex is responsible for higher brain functions such as learning, memory and perception. Developmental abnormalities of the cerebellum and cerebral cortex are relatively frequent in human patients and are associated with autism, intellectual disability and hydrocephalus. In our laboratory we use the following approaches and techniques: analysis of knockout and transgenic mice, genetic fate mapping, in utero electroporation, explants, laser capture microdissection, in situ hybridization RNA-seq, and immunohistochemistry.

Representative Publications

  • Choudhri AF, Sable HJ, Chizhikov VV, Buddington KK, Buddington RK. Parenteral nutrition compromises neurodevelopment of preterm pigs. J Nutr. 2014 Dec;144(12):1920-7. doi: 10.3945/jn.114.197145. Epub 2014 Oct 23. PubMed PMID: 25342697.
  • Millen KJ, Steshina EY, Iskusnykh IY, Chizhikov VV. Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1777-86. doi: 10.1073/pnas.1315024111. Epub 2014 Apr 14. PubMed PMID: 24733890; PubMed Central PMCID: PMC4035921.
  • Curry CJ, Rosenfeld JA, Grant E, Gripp KW, Anderson C, Aylsworth AS, Saad TB, Chizhikov VV, Dybose G, Fagerberg C, Falco M, Fels C, Fichera M, Graakjaer J, Greco D, Hair J, Hopkins E, Huggins M, Ladda R, Li C, Moeschler J, Nowaczyk MJ, Ozmore JR, Reitano S, Romano C, Roos L, Schnur RE, Sell S, Suwannarat P, Svaneby D, Szybowska M, Tarnopolsky M, Tervo R, Tsai AC, Tucker M, Vallee S, Wheeler FC, Zand DJ, Barkovich AJ, Aradhya S, Shaffer LG, Dobyns WB. The duplication 17p13.3 phenotype: analysis of 21 families delineates developmental, behavioral and brain abnormalities, and rare variant phenotypes. Am J Med Genet A. 2013 Aug;161A(8):1833-52. doi: 10.1002/ajmg.a.35996. Epub 2013 Jun 27. PubMed PMID: 23813913.
  • Blank MC, Grinberg I, Aryee E, Laliberte C, Chizhikov VV, Henkelman RM, Millen KJ. Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis. Development. 2011 Mar;138(6):1207-16. doi: 10.1242/dev.054114. Epub 2011 Feb 9. PubMed PMID: 21307096; PubMed Central PMCID: PMC3042874.
  • Swanson DJ, Steshina EY, Wakenight P, Aldinger KA, Goldowitz D, Millen KJ, Chizhikov VV. Phenotypic and genetic analysis of the cerebellar mutant tmgc26, a new ENU-induced ROR-alpha allele. Eur J Neurosci. 2010 Sep;32(5):707-16. doi: 10.1111/j.1460-9568.2010.07330.x. Epub 2010 Aug 16. PubMed PMID: 20722722; PubMed Central PMCID: PMC2974799.
  • Chizhikov VV, Lindgren AG, Mishima Y, Roberts RW, Aldinger KA, Miesegaes GR, Currle DS, Monuki ES, Millen KJ. Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10725-30. doi: 10.1073/pnas.0910786107. Epub 2010 May 24. PubMed PMID: 20498066; PubMed Central PMCID: PMC2890798.

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