Julio F. Cordero-Morales, Ph.D.

Julio F. Cordero-Morales, Ph.D.

Assistant Professor
Department of Physiology
The University of Tennessee
Health Science Center


The University of Tennessee Health Science Center
894 Union Avenue
Memphis, TN 38163
Office: 356A Nash Research Building
Lab: 356, 360 and 361 Nash Research Building
Office: (901) 448-8206
Lab: (901) 448-8205
Email: Julio F. Cordero-Morales
Website: http://corderovasquezlab.weebly.com

Education

  • Postdoctoral: University of California at San Francisco, Department of Physiology
  • Ph.D.: University of Virginia, Department of Physiology, Molecular Physiology and Biological Physics Program
  • Licentiate in Biology: Universidad Central de Venezuela, Department of Cell biology

Research Interests

Our research is focused on understanding the biochemical, structural, and cellular mechanisms by which sensory receptors (e.g., transient receptor potential and potassium ion channels) contribute to somatosensation. These sensory receptors are polymodal membrane proteins that respond to a broad range of physical (e.g., heat, cold, and pressure) and chemical (e.g., acid, irritants, and inflammatory mediators) stimuli to depolarize sensory neurons and elicit or intensify inflammatory pain. Specifically, we are interested in determine how different stimuli induce channel activation and identifying regions that specify stimuli detection. Our laboratory follows two main avenues: (1) in vitro biochemical and biophysical approaches to study ion channel regulation in response to different physical and chemical stimuli. (2) in vivo approaches to characterize sensory receptors with novel physiological roles. Our research involves a multidisciplinary approach that includes biochemical procedures, electrophysiological and structural methods together with molecular genetics and behavior experiments.

Representative Publications

  • Caires R, Sierra-Valdez FJ, Millet JRM, Herwig JD, Roan E, Vásquez V, Cordero-Morales JF. Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling. Cell Rep. 2017 Oct 3;21(1):246-258. doi: 10.1016/j.celrep.2017.09.029. PubMed PMID: 28978477.
  • Velisetty P, Stein RA, Sierra-Valdez FJ, Vásquez V, Cordero-Morales JF. Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic Analysis. Sci Rep. 2017 Aug 29;7(1):9861. doi: 10.1038/s41598-017-10426-7. PubMed PMID: 28852163; PubMed Central PMCID: PMC5575240.
  • Cao E, Cordero-Morales JF, Liu B, Qin F, Julius D. TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids. Neuron. 2013 Feb 20;77(4):667-79. doi: 10.1016/j.neuron.2012.12.016. PubMed PMID: 23439120; PubMed Central PMCID: PMC3583019.
  • Raghuraman H, Cordero-Morales JF, Jogini V, Pan AC, Kollewe A, Roux B, Perozo E. Mechanism of Cd2+ coordination during slow inactivation in potassium channels. Structure. 2012 Aug 8;20(8):1332-42. doi: 10.1016/j.str.2012.03.027. Epub 2012 Jul 5. PubMed PMID: 22771214; PubMed Central PMCID: PMC3846092.
  • Cordero-Morales JF, Gracheva EO, Julius D. Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1184-91. doi: 10.1073/pnas.1114124108. Epub 2011 Sep 19. PubMed PMID: 21930928; PubMed Central PMCID: PMC3219143.
  • Ferrer T, Cordero-Morales JF, Arias M, Ficker E, Medovoy D, Perozo E, Tristani-Firouzi M. Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway. J Biol Chem. 2011 Nov 11;286(45):39091-9. doi: 10.1074/jbc.M111.292060. Epub 2011 Sep 9. PubMed PMID: 21908602; PubMed Central PMCID: PMC3234734.

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