Catherine Kaczorowski, Ph.D.

Catherine Kaczorowski, Ph.D.

Assistant Professor
Department of Anatomy and Neurobiology


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Tel: (901) 448-2178
Fax: (901) 448-7193
Labs: 228 Wittenborg Anatomy Building
Office: 231 A Wittenborg Anatomy Building
Email: Catherine Kaczorowski



Spotlight Interview

American Federation for Aging Research

Education

  • Ph.D. Institution: Northwestern University, Neuroscience
  • Postdoctoral: Medical College of Wisconsin and University of Wisconsin-Milwaukee, Physiology and Bioengineering & Biotechnology

Mission

To identify early causative events that underlie cognitive deficits associated with 'normal' aging and Alzheimer's disease. Using multidisciplinary approaches that combine innovative high resolution and high throughput membrane proteomics, transcriptomics, viral-based gene transduction approaches, behavioral assays, and electrophysiology, our research aims to understand how misregulated membrane proteins in the hippocampus of aging and AD mouse models alter hippocampal neuron excitability and memory. Our goal is to transform basic discoveries into treatments that prevent and cure dementias in aging.

Representative Publications

  • Neuner SM, Wilmott LA, Hoffmann BR, Mozhui K, Kaczorowski CC. Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. Behav Brain Res. 2016 Jun 2. pii: S0166-4328(16)30356-4. doi: 10.1016/j.bbr.2016.06.002. [Epub ahead of print] PubMed PMID: 27265785.
  • Graves AR, Moore SJ, Spruston N, Tryba AK, Kaczorowski CC. Brain derived neurotrophic factor differentially modulates excitability of two classes of hippocampal output neurons. J Neurophysiol. 2016 May 4:jn.00186.2016. doi: 10.1152/jn.00186.2016. [Epub ahead of print] PubMed PMID: 27146982.
  • Prisco AR, Hoffmann BR, Kaczorowski CC, McDermott-Roe C, Stodola TJ, Exner EC, Greene AS. TNFα Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. Stem Cells. 2016 Feb 11. doi: 10.1002/stem.2339. [Epub ahead of print] PubMed PMID: 26867147.
  • Clayton T, Poe MM, Rallapalli S, Biawat P, Savić MM, Rowlett JK, Gallos G, Emala CW, Kaczorowski CC, Stafford DC, Arnold LA, Cook JM. A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model. Int J Med Chem. 2015;2015:430248. doi: 10.1155/2015/430248. Epub 2015 Nov 10. Review. PubMed PMID: 26682068; PubMed Central PMCID: PMC4657098.
  • Wei W, Pham K, Gammons JW, Sutherland D, Liu Y, Smith A, Kaczorowski CC, O'Connell KM. Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY neurons in mice. Sci Rep. 2015 Nov 23;5:16810. doi: 10.1038/srep16810. PubMed PMID: 26592769; PubMed Central PMCID: PMC4655371.
  • Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell KM, Tryba AK, Greene AS, Savio Chan C, Kaczorowski CC. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res. 2015 Mar 15;281:69-77. doi: 10.1016/j.bbr.2014.12.018. Epub 2014 Dec 13. PubMed PMID: 25513972; PubMed Central PMCID: PMC4677051.

View more references (pubmed link)