Catherine Kaczorowski, Ph.D.

Catherine Kaczorowski, Ph.D.

Assistant Professor
Department of Anatomy and Neurobiology


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Tel: (901) 448-2178
Fax: (901) 448-7193
Labs: 228 Wittenborg Anatomy Building
Office: 231 A Wittenborg Anatomy Building
Email: Catherine Kaczorowski



Education

  • Ph.D. Institution: Northwestern University, Neuroscience
  • Postdoctoral: Medical College of Wisconsin and University of Wisconsin-Milwaukee, Physiology and Bioengineering & Biotechnology

Mission

To identify early causative events that underlie cognitive deficits associated with 'normal' aging and Alzheimer's disease. Using multidisciplinary approaches that combine innovative high resolution and high throughput membrane proteomics, transcriptomics, viral-based gene transduction approaches, behavioral assays, and electrophysiology, our research aims to understand how misregulated membrane proteins in the hippocampus of aging and AD mouse models alter hippocampal neuron excitability and memory. Our goal is to transform basic discoveries into treatments that prevent and cure dementias in aging.

Representative Publications

  • Kaczorowski CC, Stodola TJ, Hoffmann BR, Prisco AR, Liu PY, Didier DN, Karcher JR, Liang M, Jacob HJ, Greene AS. Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. Physiol Genomics. 2013 Nov 1;45(21):999-1011. doi: 10.1152/physiolgenomics.00097.2013. Epub 2013 Sep 10. PubMed PMID: 24022221; PubMed Central PMCID: PMC3841789.
  • Kaczorowski CC. Bidirectional pattern-specific plasticity of the slow afterhyperpolarization in rats: role for high-voltage activated Ca2+ channels and I h. Eur J Neurosci. 2011 Dec;34(11):1756-65. doi: 10.1111/j.1460-9568.2011.07899.x. Epub 2011 Nov 20. PubMed PMID: 22098477; PubMed Central PMCID: PMC3228416.
  • Tryba AK, Kaczorowski CC, Ben-Mabrouk F, Elsen FP, Lew SM, Marcuccilli CJ. Rhythmic intrinsic bursting neurons in human neocortex obtained from pediatric patients with epilepsy. Eur J Neurosci. 2011 Jul;34(1):31-44. doi: 10.1111/j.1460-9568.2011.07746.x. PubMed PMID: 21722205.
  • Kaczorowski CC, Davis SJ, Moyer JR Jr. Aging redistributes medial prefrontal neuronal excitability and impedes extinction of trace fear conditioning. Neurobiol Aging. 2012 Aug;33(8):1744-57. doi: 10.1016/j.neurobiolaging.2011.03.020. Epub 2011 Apr 30. PubMed PMID: 21531046.
  • Kaczorowski CC, Sametsky E, Shah S, Vassar R, Disterhoft JF. Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease. Neurobiol Aging. 2011 Aug;32(8):1452-65. doi: 10.1016/j.neurobiolaging.2009.09.003. Epub 2009 Oct 14. PubMed PMID: 19833411; PubMed Central PMCID: PMC2888747.
  • Kaczorowski CC, Disterhoft JF. Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice. Learn Mem. 2009 May 23;16(6):362-6. doi: 10.1101/lm.1365609. Print 2009 Jun. PubMed PMID: 19470651; PubMed Central PMCID: PMC2704100.

View more references (pubmed link)