Bob M. Moore II, Ph.D.

Bob M. Moore II, Ph.D.

Professor


Department of Pharmaceutical Sciences


The University of Tennessee Health Science Center
874 Union Avenue, Room 327D
Memphis, TN 38163
Tel: (901) 448-6085
Fax: (508) 448-6828
Email: Bob M. Moore



Education

  • B.S. in Chemistry, Indiana State University, 1983
  • M.S. in Chemistry, Indiana State University, 1989
  • Ph.D. (Medicinal Chemistry), University of Kansas, 1995

Research Interests

Research in Dr. Moore's lab integrates synthetic organic chemistry, computational chemistry and biological assays aimed at developing new chemotherapeutic entities. The current areas of research include:

  1. Development of cannabinoid receptor (CB1 and CB2) agonist and antagonist.
  2. Development of novel therapies for combat causality care with emphasis on hemorrhagic shock and hemostasis.
  3. Development of GPRC directed anti-neoplastic agents.
  4. Combination drug therapies for the treatment of sepsis, stroke and ischemic brain conditions.

Representative Publications

  • Moore BM, Jerry Jou C, Tatalovic M, Kaufman ES, Kline DD, Kunze DL. The Kv1.1 null mouse, a model of sudden unexpected death in epilepsy (SUDEP). Epilepsia. 2014 Nov;55(11):1808-16. doi: 10.1111/epi.12793. Epub 2014 Nov 6. PubMed PMID: 25377007.
  • Moore BM, Brady SL, Mirro AE, Kaufman RA. Size-specific dose estimate (SSDE) provides a simple method to calculate organ dose for pediatric CT examinations. Med Phys. 2014 Jul;41(7):071917. doi: 10.1118/1.4884227. PubMed PMID: 24989395.
  • Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D Jr, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PI, Duzkale H, Dworzyński P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJ, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth K, Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt S, Herman G, Lamb-Thrush D, McBride KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrečić L, Palandačić A, Peterlin B, Torkamani A, Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, Bai Y, Huang Y, Fang F, Zhang Y, Wang Z, Barrera J, Garcia-Lobo JM, González-Lamuño D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M, Hart RK, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M, Li P, Kong Y, Alexander AC, Albertyn ZI, Boycott KM, Bulman DE, Gordon PM, Innes AM, Knoppers BM, Majewski J, Marshall CR, Parboosingh JS, Sawyer SL, Samuels ME, Schwartzentruber J, Kohane IS, Margulies DM. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol. 2014 Mar 25;15(3):R53. doi: 10.1186/gb-2014-15-3-r53. PubMed PMID: 24667040; PubMed Central PMCID: PMC4073084.
  • Brocato B, Zoerner AA, Janjetovic Z, Skobowiat C, Gupta S, Moore BM 2nd, Slominski A, Zhang J, Schenone M, Phinehas R, Ferry RJ Jr, Dick E Jr, Hubbard GB, Mari G, Schlabritz-Loutsevitch N. Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta. 2013 Nov;34(11):983-9. doi: 10.1016/j.placenta.2013.08.007. Epub 2013 Sep 2. PubMed PMID: 24008071; PubMed Central PMCID: PMC3827983.
  • Brady SL, Moore BM, Yee BS, Kaufman RA. Pediatric CT: implementation of ASIR for substantial radiation dose reduction while maintaining pre-ASIR image noise. Radiology. 2014 Jan;270(1):223-31. doi: 10.1148/radiol.13122578. Epub 2013 Oct 28. PubMed PMID: 23901128.
  • Overman AE, Liu M, Kurachek SC, Shreve MR, Maynard RC, Mammel MC, Moore BM. Tracheostomy for infants requiring prolonged mechanical ventilation: 10 years' experience. Pediatrics. 2013 May;131(5):e1491-6. doi: 10.1542/peds.2012-1943. Epub 2013 Apr 8. PubMed PMID: 23569088.

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