Dr. Abbas Babajani-Feremi, PhD


Abbas Babajani-Feremi

Assistant Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center


Le Bonheur Children's Medical Center
51 N. Dunlap St., Ste P320
Outpatient Center
Memphis, TN 38105
Phone: (901) 287-4612
Email: Abbas Babajani-Feremi

Education

  • Ph.D. Institution: University of Tehran, Biomedical Engineering
  • Postdoctoral: Henry Ford Health System, Detroit, MI; Washington University School of Medicine, St Louis, MO - Human Connectome Project (HCP)

Research Keywords

  • Signal and image processing
  • Medical imaging
  • Brain connectivity analysis
  • Functional magnetic resonance imaging (fMRI)
  • Magnetoencephalography (MEG) and electroencephalography (EEG)
  • Electrocorticography (ECoG) (or intracranial EEG (iEEG))
  • Transcranial magnetic stimulation (TMS)
  • Dynamic contrast enhancement MRI (DCE-MRI)
  • Epilepsy, Alzheimer’s disease, sleep disorder, and traumatic brain injury (TBI)

Research Interest

My research area is in the field of medical image and signal processing and analysis. In particular, I am interested in application of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), electroencephalography (EEG), and electrocorticography (ECoG) in diagnostic and treatment of patients with epilepsy, Alzheimer’s disease, sleep disorder, and traumatic brain injury (TBI). My main research interest is the application of the brain connectivity analysis using fMRI and MEG/EEG in diagnostic and treatment of these diseases. For instance, I am utilizing the resting-state fMRI (rs-fMRI) brain connectivity analysis in Alzheimer’s disease (AD). We combine the machine learning algorithm, e.g. the support vector machine (SVM), with the graph theoretical approach to develop an accurate diagnostic tool based on the rs-fMRI for distinguishing three groups of subjects: healthy control, patients with mild cognitive impairment, and patients with AD.

         Another research area that I have been working is the functional, and in particular language, mapping using the intracranial ECoG recording, fMRI, MEG, and transcranial magnetic stimulation (TMS). Specifically, I am interested in studying enhancement of the power of ECoG recording in the high gamma (> 50 Hz) frequency range during different cognitive tasks (e.g. language and memory).

I am also interested in applications of the dynamic contrast-enhancement MRI (DCE-MRI) for characterizing tumors. I worked on determining the tumor size and expression of vascular endothelial growth factor receptors in treated and non-treated implanted glioma (U-251) by in vivo DCE-MRI and single photon emission computed tomography (SPECT). We also assessed the utility of non-model based ‘semi-quantitative’ indices derived from DCE-MRI for differentiating treatment induced necrosis from recurrent/progressive tumor patients. The proposed semi quantitative indices were robust and reproducible clinical tool that can help in quick and efficient decision-making in evaluating efficiency of new anti-angiogenic agents. 

Representative Publications

  • Narayana S, Mudigoudar B, Babajani-Feremi A, Choudhri AF, Boop FA. Successful motor mapping with transcranial magnetic stimulation in an infant: A case report. Neurology. 2017 Nov 14;89(20):2115-2117. doi: 10.1212/WNL.0000000000004650. Epub 2017 Oct 11. PubMed PMID: 29021352.
  • Papanicolaou AC, Wheless JW, Babajani-Feremi A, Narayana S, Rezaie R, Choudhri A, Boop F. Letter re: Practice guideline summary: Use of fMRI in the presurgical evaluation of patients with epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2017 Aug 8;89(6):640. doi: 10.1212/WNL.0000000000004204. PubMed PMID: 28784636.
  • Elahian B, Yeasin M, Mudigoudar B, Wheless JW, Babajani-Feremi A. Identifying seizure onset zone from electrocorticographic recordings: A machine learning approach based on phase locking value. Seizure. 2017 Oct;51:35-42. doi: 10.1016/j.seizure.2017.07.010. Epub 2017 Jul 25. PubMed PMID: 28772200.
  • Papanicolaou AC, Kilintari M, Rezaie R, Narayana S, Babajani-Feremi A. The Role of the Primary Sensory Cortices in Early Language Processing. J Cogn Neurosci. 2017 Oct;29(10):1755-1765. doi: 10.1162/jocn_a_01147. Epub 2017 May 30. PubMed PMID: 28557692.
  • Hojjati SH, Ebrahimzadeh A, Khazaee A, Babajani-Feremi A; Alzheimer’s Disease Neuroimaging Initiative. Predicting conversion from MCI to AD using resting-state fMRI, graph theoretical approach and SVM. J Neurosci Methods. 2017 Apr 15;282:69-80. doi: 10.1016/j.jneumeth.2017.03.006. Epub 2017 Mar 9. PubMed PMID: 28286064.
  • Babajani-Feremi A. Neural Mechanism Underling Comprehension of Narrative Speech and Its Heritability: Study in a Large Population. Brain Topogr. 2017 Feb 18. doi: 10.1007/s10548-017-0550-6. [Epub ahead of print] PubMed PMID: 28214981.

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