William E. Armstrong, Ph.D.

William E. Armstrong, Ph.D.

Neuroscience Institute Director

Professor
Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-5995
Fax: (901) 448-7193
Lab: 210 Wittenborg Anatomy Building
Email: William E. Armstrong



Education

  • Ph.D. Institution: Michigan State University, Department of Psychology, Neuroscience Program
  • Postdoctoral: University of Rochester School of Medicine, Department of Anatomy; University of Geneva School of Medicine, Department of Physiology

Research Interests

My research is focused on understanding how neurosecretory neurons of the rat hypothalamo-neurohypophysial system release the hormones oxytocin and vasopressin into the general circulation. Current experiments include: 1) conventional intracellular and whole cell recordings of immunocytochemically identified oxytocin and vasopressin neurons, to determine differences between oxytocin and vasopressin neurons and how these differences relate to firing patterns during hormone release; 2) combined light and electron microscopic morphological studies to characterize the synaptic inputs to these neurons and understand the neural circuits which control the firing pattern of these neurons; and 3) characterizing plasticity in the intrinsic and synaptic properties of these neurons as a function of endocrine state.

Representative Publications

  • Wang L, Ennis M, Szabo G, Armstrong WE. Characteristics of GABAergic and Cholinergic Neurons in the Perinuclear Zone of Mouse Supraoptic Nucleus. J Neurophysiol. 2014 Nov 5:jn.00561.2014. doi: 10.1152/jn.00561.2014. [Epub ahead of print] PubMed PMID: 25376783.
  • Tokita K, Armstrong WE, St John SJ, Boughter JD Jr. Activation of lateral hypothalamus-projecting parabrachial neurons by intraorally delivered gustatory stimuli. Front Neural Circuits. 2014 Jul 29;8:86. doi: 10.3389/fncir.2014.00086. eCollection 2014. PubMed PMID: 25120438; PubMed Central PMCID: PMC4114292.
  • Guan D, Armstrong WE, Foehring RC. Kv2 channels regulate firing rate in pyramidal neurons from rat sensorimotor cortex. J Physiol. 2013 Oct 1;591(Pt 19):4807-25. doi: 10.1113/jphysiol.2013.257253. Epub 2013 Jul 22. PubMed PMID: 23878373; PubMed Central PMCID: PMC3800456.
  • Scroggs R, Wang L, Teruyama R, Armstrong WE. Variation in sodium current amplitude between vasopressin and oxytocin hypothalamic supraoptic neurons. J Neurophysiol. 2013 Feb;109(4):1017-24. doi: 10.1152/jn.00812.2012. Epub 2012 Nov 21. PubMed PMID: 23175803; PubMed Central PMCID: PMC3569137.
  • Mozhui K, Lu L, Armstrong WE, Williams RW. Sex-specific modulation of gene expression networks in murine hypothalamus. Front Neurosci. 2012 May 11;6:63. doi: 10.3389/fnins.2012.00063. eCollection 2012. PubMed PMID: 22593731; PubMed Central PMCID: PMC3350311.
  • Teruyama R, Sakuraba M, Wilson LL, Wandrey NE, Armstrong WE. Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E273-85. doi: 10.1152/ajpendo.00407.2011. Epub 2011 Nov 1. PubMed PMID: 22045317; PubMed Central PMCID: PMC3287361.

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