Stanislav S. Zakharenko, M.D., Ph.D.

Stanislav S. Zakharenko, M.D., Ph.D.

Associate Member
Department of Developmental Neurobiology
St. Jude Children's Research Hospital

Affiliate Associate Professor
Department of Anatomy and Neurobiology

St. Jude Children's Research Hospital
332 N. Lauderdale
Memphis, TN 38105-2794
Tel: (901) 595-3837
Fax: (901) 595-3143
Lab: MS 323, Room D2025B
Email: Stanislav S. Zakharenko



Research Interests

  • Functional organization and synaptic plasticity in the auditory cortex
  • Molecular and cellular mechanisms of cognitive deficits during schizophrenia
  • Synaptic plasticity in the hippocampus

Representative Publications

  • Chun S, Du F, Westmoreland JJ, Han SB, Wang YD, Eddins D, Bayazitov IT, Devaraju P, Yu J, Mellado Lagarde MM, Anderson K, Zakharenko SS. Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion. Nat Med. 2016 Nov 28. doi: 10.1038/nm.4240. [Epub ahead of print] PubMed PMID: 27892953.
  • Diouf B, Devaraju P, Janke LJ, Fan Y, Frase S, Eddins D, Peters JL, Kim J, Pei D, Cheng C, Zakharenko SS, Evans WE. Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice. Sci Rep. 2016 Aug 1;6:30757. doi: 10.1038/srep30757. PubMed PMID: 27476972; PubMed Central PMCID: PMC4967871.
  • Devaraju P, Yu J, Eddins D, Mellado-Lagarde MM, Earls LR, Westmoreland JJ, Quarato G, Green DR, Zakharenko SS. Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium. Mol Psychiatry. 2016 May 17. doi: 10.1038/mp.2016.75. [Epub ahead of print] PubMed PMID: 27184122; PubMed Central PMCID: PMC5114177.
  • Gingras S, Earls LR, Howell S, Smeyne RJ, Zakharenko SS, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22. doi: 10.1523/JNEUROSCI.2056-14.2015. PubMed PMID: 26203146; PubMed Central PMCID: PMC4510291.
  • Chun S, Westmoreland JJ, Bayazitov IT, Eddins D, Pani AK, Smeyne RJ, Yu J, Blundon JA, Zakharenko SS. Specific disruption of thalamic inputs to the auditory cortex in schizophrenia models. Science. 2014 Jun 6;344(6188):1178-82. doi: 10.1126/science.1253895. PubMed PMID: 24904170; PubMed Central PMCID: PMC4349506.
  • Earls LR, Westmoreland JJ, Zakharenko SS. Non-coding RNA regulation of synaptic plasticity and memory: implications for aging. Ageing Res Rev. 2014 Sep;17:34-42. doi: 10.1016/j.arr.2014.03.004. Review. PubMed PMID: 24681292; PubMed Central PMCID: PMC4145026.

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