Stanislav S. Zakharenko, M.D., Ph.D.

Stanislav S. Zakharenko, M.D., Ph.D.

Associate Member
Department of Developmental Neurobiology
St. Jude Children's Research Hospital

Affiliate Associate Professor
Department of Anatomy and Neurobiology

St. Jude Children's Research Hospital
332 N. Lauderdale
Memphis, TN 38105-2794
Tel: (901) 595-3837
Fax: (901) 595-3143
Lab: MS 323, Room D2025B
Email: Stanislav S. Zakharenko



Research Interests

  • Functional organization and synaptic plasticity in the auditory cortex
  • Molecular and cellular mechanisms of cognitive deficits during schizophrenia
  • Synaptic plasticity in the hippocampus

Representative Publications

  • Eom TY, Bayazitov IT, Anderson K, Yu J, Zakharenko SS. Schizophrenia-Related Microdeletion Impairs Emotional Memory through MicroRNA-Dependent Disruption of Thalamic Inputs to the Amygdala. Cell Rep. 2017 May 23;19(8):1532-1544. doi: 10.1016/j.celrep.2017.05.002. PubMed PMID: 28538174; PubMed Central PMCID: PMC5457478.
  • Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP. CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene. Cell Rep. 2017 Jan 10;18(2):352-366. doi: 10.1016/j.celrep.2016.12.052. PubMed PMID: 28076781; PubMed Central PMCID: PMC5261823.
  • Devaraju P, Zakharenko SS. Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease. Bioessays. 2017 Feb;39(2). doi: 10.1002/bies.201600177. Epub 2017 Jan 3. PubMed PMID: 28044359; PubMed Central PMCID: PMC5304421.
  • Chun S, Du F, Westmoreland JJ, Han SB, Wang YD, Eddins D, Bayazitov IT, Devaraju P, Yu J, Mellado Lagarde MM, Anderson K, Zakharenko SS. Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion. Nat Med. 2017 Jan;23(1):39-48. doi: 10.1038/nm.4240. Epub 2016 Nov 28. PubMed PMID: 27892953; PubMed Central PMCID: PMC5218899.
  • Diouf B, Devaraju P, Janke LJ, Fan Y, Frase S, Eddins D, Peters JL, Kim J, Pei D, Cheng C, Zakharenko SS, Evans WE. Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice. Sci Rep. 2016 Aug 1;6:30757. doi: 10.1038/srep30757. PubMed PMID: 27476972; PubMed Central PMCID: PMC4967871.
  • Devaraju P, Yu J, Eddins D, Mellado-Lagarde MM, Earls LR, Westmoreland JJ, Quarato G, Green DR, Zakharenko SS. Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium. Mol Psychiatry. 2016 May 17. doi: 10.1038/mp.2016.75. [Epub ahead of print] PubMed PMID: 27184122; PubMed Central PMCID: PMC5114177.

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