Steven J. Tavalin, Ph.D.

Steven J. Tavalin, Ph.D.

Associate Professor
Department of Pharmacology


The University of Tennessee Health Science Center
2105 Crowe Research Building
874 Union Avenue
Memphis, TN 38163
Phone: (901) 448-3007
Email: Steven J. Tavalin



Education

  • Ph.D. Institution: Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
  • Postdoctoral: Vollum Institute, Oregon Health Sciences University, Portland, OR

Link

Research Interests

How do neurons modify their behavior in response to patterns of activity? To address this question my research employs a combination of biochemical, and electrophysiological techniques. Specifically, I am interested in understanding the mechanisms by which intracellular signalling enzymes are directed towards ion channels to allow modulation of channel activity and its impact on excitatory transmission and neuronal excitability.

Representative Publications

  • Chowdhury D, Marco S, Brooks IM, Zandueta A, Rao Y, Haucke V, Wesseling JF, Tavalin SJ, PĆ©rez-OtaƱo I. Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors. J Neurosci. 2013 Feb 27;33(9):4151-64. doi: 10.1523/JNEUROSCI.2721-12.2013. PubMed PMID: 23447623; PubMed Central PMCID: PMC3682218.
  • Le AV, Tavalin SJ, Dodge-Kafka KL. Identification of AKAP79 as a protein phosphatase 1 catalytic binding protein. Biochemistry. 2011 Jun 14;50(23):5279-91. doi: 10.1021/bi200089z. Epub 2011 May 16. PubMed PMID: 21561082; PubMed Central PMCID: PMC3115558.
  • Brooks IM, Tavalin SJ. Ca2+/calmodulin-dependent protein kinase II inhibitors disrupt AKAP79-dependent PKC signaling to GluA1 AMPA receptors. J Biol Chem. 2011 Feb 25;286(8):6697-706. doi: 10.1074/jbc.M110.183558. Epub 2010 Dec 14. PubMed PMID: 21156788; PubMed Central PMCID: PMC3057809.
  • Nikandrova YA, Jiao Y, Baucum AJ, Tavalin SJ, Colbran RJ. Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity. J Biol Chem. 2010 Jan 8;285(2):923-34. doi: 10.1074/jbc.M109.033985. Epub 2009 Oct 26. PubMed PMID: 19858198; PubMed Central PMCID: PMC2801293.
  • Liang Y, Tavalin SJ. Auxiliary beta subunits differentially determine pka utilization of distinct regulatory sites on Cav1.3 L type Ca2+ channels. Channels (Austin). 2007 Mar-Apr;1(2):102-12. Epub 2007 Apr 12. PubMed PMID: 18690020.
  • Tavalin SJ. AKAP79 selectively enhances protein kinase C regulation of GluR1 at a Ca2+-calmodulin-dependent protein kinase II/protein kinase C site. J Biol Chem. 2008 Apr 25;283(17):11445-52. doi: 10.1074/jbc.M709253200. Epub 2008 Feb 27. PubMed PMID: 18305116; PubMed Central PMCID: PMC2431053.

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