Rebecca A. Prosser, Ph.D.
Department of Biochemistry, Cellular and Molecular Biology
The University of Tennessee, Knoxville
M313 Walters Life Science Building
Knoxville, TN 37996-0810
Phone: (423) 974-5148
Fax: (423) 974-6306
Email: Rebecca A. Prosser
- Ph.D. Institution: University of Illinois at Urbana-Champaign, IL
- Postdoctoral: Stanford University, Stanford, CA
All organisms share the characteristics that their behavior and physiology fluctuate over the course of the 24 hours day. These daily, or circadian, rhythms are controlled by clocks endogenous to the organisms, and they normally are synchronized to the external environment by the daily solar cycle. Research in my laboratory explores the cellular basis of mammalian circadian rhythms. The mammalian circadian clock is located in an area of the brain called the suprachiasmatic nucleus. While much is known about the cell types in this region and the areas of the brain that send it information, the mechanisms involved in producing these rhythms remain obscure. My research is focused on both the cellular processes involved in rhythm production as well as how the clock is modulated by other brain regions. The primary approach I have used for these studies is to study the rat suprachiasmatic nucleus after isolation in a brain slice preparation. The techniques used in these studies include electrophysiological, neuropharmacology, and radioimmunoassay. An increased understanding of how the clock works and how it can be manipulated should help alleviate problems associated with circadian clock dysfunction (including some sleep and manic depressive disorders) and with clock desynchronization (which occurs during jet lab and with shift work schedules).
- Prosser RA, Stowie A, Amicarelli M, Nackenoff AG, Blakely RD, Glass JD. Cocaine modulates mammalian circadian clock timing by decreasing serotonin transport in the SCN. Neuroscience. 2014 Jun 17;275C:184-193. doi: 10.1016/j.neuroscience.2014.06.012. [Epub ahead of print] PubMed PMID: 24950119.
- Lindsay JH, Glass JD, Amicarelli M, Prosser RA. The mammalian circadian clock in the suprachiasmatic nucleus exhibits rapid tolerance to ethanol in vivo and in vitro. Alcohol Clin Exp Res. 2014 Mar;38(3):760-9. doi: 10.1111/acer.12303. Epub 2014 Feb 11. PubMed PMID: 24512529.
- Yamada Y, Prosser RA. Copper chelation and exogenous copper affect circadian clock phase resetting in the suprachiasmatic nucleus in vitro. Neuroscience. 2014 Jan 3;256:252-61. doi: 10.1016/j.neuroscience.2013.10.033. Epub 2013 Oct 23. PubMed PMID: 24161278.
- Brager AJ, Stowie AC, Prosser RA, Glass JD. The mPer2 clock gene modulates cocaine actions in the mouse circadian system. Behav Brain Res. 2013 Apr 15;243:255-60. doi: 10.1016/j.bbr.2013.01.014. Epub 2013 Jan 17. PubMed PMID: 23333842; PubMed Central PMCID: PMC4004096.
- Besing RC, Hablitz LM, Paul JR, Johnson RL, Prosser RA, Gamble KL. Neuropeptide Y-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner. Chronobiol Int. 2012 Mar;29(2):91-102. doi: 10.3109/07420528.2011.649382. PubMed PMID: 22324550; PubMed Central PMCID: PMC3568491.
- Glass JD, Brager AJ, Stowie AC, Prosser RA. Cocaine modulates pathways for photic and nonphotic entrainment of the mammalian SCN circadian clock. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15;302(6):R740-50. doi: 10.1152/ajpregu.00602.2011. Epub 2012 Jan 4. PubMed PMID: 22218419.