Peter J McKinnon, Ph.D.

Peter J McKinnon, Ph.D.

Department of Genetics and Tumor
Cell Biology
St. Jude Children's Research Hospital

Affiliated Professor
Department of Anatomy and Neurobiology


St. Jude Children's Research Hospital
Department Genetics & Tumor Cell Biology
262 Danny Thomas Place
Memphis, TN 38105
Phone (901) 595-2700
Fax (901) 525-6035
Email: Peter J McKinnon



Education

  • Ph.D. Institution: The Flinders Universiry of South Australia, Adelaide, Australia
  • Postdoctoral: The Roche Institute of Molecular Biology, Nutley, New Jersey

Link

Research Interests

Our goal is to understand the role of the DNA damage response in the nervous system, and how this functions to prevent disease. The response to genotoxic stress is a prerequisite for development of the nervous system. Mutations in a variety of DNA damage-response factors can lead to human diseases that are characterized by pronounced neuropathology. In many of these syndromes the neurological component is amongst the most deleterious aspects of the disease. Because the nervous system poses a particular challenge in terms of clinical intervention, understanding how DNA repair deficiency impacts the nervous system will be important for design of therapies targeted at ameliorating neuropathology including neurodegeneration and brain tumors. For more information please see: http://www.stjude.org/mckinnon

Representative Publications

  • Hoch NC, Hanzlikova H, Rulten SL, T√©treault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium., Yoon G, Caldecott KW. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature. 2017 Jan 5;541(7635):87-91. doi: 10.1038/nature20790. PubMed PMID: 28002403; PubMed Central PMCID: PMC5218588.
  • Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ. DNA-PKcs, ATM and ATR interplay maintains genome integrity during neurogenesis. J Neurosci. 2016 Dec 15. pii: 4213-15. [Epub ahead of print] PubMed PMID: 27980111.
  • McKinnon PJ. Topoisomerases and the regulation of neural function. Nat Rev Neurosci. 2016 Nov;17(11):673-679. doi: 10.1038/nrn.2016.101. PubMed PMID: 27630045; PubMed Central PMCID: PMC5209242.
  • Al-Khalaf MH, Blake LE, Larsen BD, Bell RA, Brunette S, Parks RJ, Rudnicki MA, McKinnon PJ, Jeffrey Dilworth F, Megeney LA. Temporal activation of XRCC1-mediated DNA repair is essential for muscle differentiation. Cell Discov. 2016 Jan 12;2:15041. doi: 10.1038/celldisc.2015.41. PubMed PMID: 27462438; PubMed Central PMCID: PMC4860966.
  • Ho Y, Li X, Jamison S, Harding HP, McKinnon PJ, Ron D, Lin W. PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis. Am J Pathol. 2016 Jul;186(7):1939-51. doi: 10.1016/j.ajpath.2016.03.004. PubMed PMID: 27181404; PubMed Central PMCID: PMC4929388.
  • Dumitrache LC, McKinnon PJ. Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic disease. Mech Ageing Dev. 2016 Apr 26. pii: S0047-6374(16)30051-3. doi: 10.1016/j.mad.2016.04.009. [Epub ahead of print] PubMed PMID: 27125728; PubMed Central PMCID: PMC5161711.

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