Mark S. LeDoux, M.D., Ph.D.

Mark S. LeDoux, M.D., Ph.D.

Professor
Department of Neurology Department of Anatomy and Neurobiology

Director
Dystonia and Huntington Disease Clinics

Director
Movement Disorders Research Laboratories


The University of Tennessee Health Science Center
855 Monroe Avenue
Suite 415 Link Building
Memphis, TN 38163
Phone: (901) 448-1662
Fax: (901) 448-7440
Email: Mark S. LeDoux



Education

  • M.D. Institution: Louisiana State University School of Medicine
  • Ph.D. Institution: University of Alabama, Birmingham, Department of Neuroscience
  • Residency Training: University of Alabama at Birmingham; University of Tennessee Health Science Center

Links

Research Interests

  • Genetics and pathobiology of primary dystonia
    • Using vertebrate and invertebrate models, human lymphoblastoid cell lines and stable transfected cell lines, we study the cellular and systems biology of dystonia-associated proteins (torsinA, THAP1, caytaxin, carbonic anhydrase 8 and epsilon-sarcoglycan).
    • Genetic contributions to late-onset primary dystonia are being examined with candidate gene, genome-wide and gene expression studies.
  • Mechanisms of neurodegeneration in Parkinson disease:  several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson disease.  To examine the potential role of TIQs in monoaminergic cell death, we have used enantiomeric-selective high-performance liquid chromatography with electrochemical detection, liquid chromatography with tandem mass spectroscopy, cell culture studies of neurotoxicity and assays of mitochondrial membrane potential.
  • Clinical trials of therapeutic interventions for movement disorders (dystonia, Huntington disease, Parkinson disease, restless legs syndrome)
  • Anatomy and computational organization of motor systems
    • The neural networks mediating suprasegmental control of the blink reflex and spontaneous blinking remain poorly understood. Viral transneuronal tracing is being used to define the integrated premotor cortical and subcortical control of levator palpebrae and orbicularis oculi motoneuron activity.
    • In isolation or via interactions with striatal-thalamo-cortical pathways, olivocerebellar structures play a critical role in disorders of motor control such as ataxia and dystonia. Using neurophysiological and molecular tools, we are dissecting the relative roles of individual network elements in the positive and negative signs characteristic of individual movement disorders.

Clinical Subspecialty Expertise

Adult and Pediatric Movement Disorders, Botulinum Toxin for Dystonia and Spasticity

Representative Publications

  • Theuns J, Verstraeten A, Sleegers K, Wauters E, Gijselinck I, Smolders S, Crosiers D, Corsmit E, Elinck E, Sharma M, Krüger R, Lesage S, Brice A, Chung SJ, Kim MJ, Kim YJ, Ross OA, Wszolek ZK, Rogaeva E, Xi Z, Lang AE, Klein C, Weissbach A, Mellick GD, Silburn PA, Hadjigeorgiou GM, Dardiotis E, Hattori N, Ogaki K, Tan EK, Zhao Y, Aasly J, Valente EM, Petrucci S, Annesi G, Quattrone A, Ferrarese C, Brighina L, Deutschländer A, Puschmann A, Nilsson C, Garraux G, LeDoux MS, Pfeiffer RF, Boczarska-Jedynak M, Opala G, Maraganore DM, Engelborghs S, De Deyn PP, Cras P, Cruts M, Van Broeckhoven C; On behalf of the GEO-PD Consortium. Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease. Neurology. 2014 Oct 17. pii: 10.1212/WNL.0000000000001012. [Epub ahead of print] PubMed PMID: 25326098.
  • Xiao J, Vemula SR, LeDoux MS. Recent advances in the genetics of dystonia. Curr Neurol Neurosci Rep. 2014 Aug;14(8):462. doi: 10.1007/s11910-014-0462-8. PubMed PMID: 24952478.
  • Vemula SR, Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Paniello RC, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Truong DD, Blitzer A, Rudzińska M, Momčilović D, Jinnah HA, Frei K, Pfeiffer RF, LeDoux MS. A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia. Mol Genet Genomic Med. 2014 May;2(3):261-72. doi: 10.1002/mgg3.67. Epub 2014 Feb 11. PubMed PMID: 24936516; PubMed Central PMCID: PMC4049367.
  • Vemula SR, Xiao J, Bastian RW, Momčilović D, Blitzer A, LeDoux MS. Pathogenic variants in TUBB4A are not found in primary dystonia. Neurology. 2014 Apr 8;82(14):1227-30. doi: 10.1212/WNL.0000000000000294. Epub 2014 Mar 5. PubMed PMID: 24598712; PubMed Central PMCID: PMC4001202.
  • Ledoux MS, Dauer WT, Warner TT. Emerging common molecular pathways for primary dystonia. Mov Disord. 2013 Jun 15;28(7):968-81. doi: 10.1002/mds.25547. Review. PubMed PMID: 23893453; PubMed Central PMCID: PMC3838975.
  • Moscovich M, LeDoux MS, Xiao J, Rampon GL, Vemula SR, Rodriguez RL, Foote KD, Okun MS. Dystonia, facial dysmorphism, intellectual disability and breast cancer associated with a chromosome 13q34 duplication and overexpression of TFDP1: case report. BMC Med Genet. 2013 Jul 13;14:70. doi: 10.1186/1471-2350-14-70. PubMed PMID: 23849371; PubMed Central PMCID: PMC3722009.

View more references (pubmed link)