Marcia G. Honig, PhD
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-5998
Fax: (901) 448-7193
Lab: 534 Johnson Building
Email: Marcia G. Honig
- PhD Institution: Yale University, Department of Biology
- Postdoctoral: State University of New York at Stony Brook, Department of Neurobiology and Behavior; University of Michigan, Department of Biology
The research in my laboratory is focused on examining the behavioral consequences of traumatic brain injury (TBI) and the associated pathological changes, through the use of a mouse model. We create the injury by delivering a high-pressure air blast to a restricted part of one side of the cranium, after anesthetizing and stabilizing the mouse to restrict its movement and shielding the rest of the head and the entire body from the blast. In terms of the biomechanical forces produced by the air blast, the functional deficits exhibited by the mice, and the widespread axonal injury later observed with histological analysis, our model very much mimics the mild TBI (i.e. concussion) sustained by humans during traumatic incidents such as sports injuries, motor vehicle accidents, and falls, where the skull remains intact. Accompanying the initial axonal injury, microglia become activated and the ensuing neuroinflammation contributes to further pathogenesis.
We are currently pursuing this in two ways. First, we are utilizing a pharmacological agent that modulates microglia in such a way as to improve the outcome from TBI, and may also provide benefit in neurodegenerative diseases such as Alzheimer’s and ALS where neuroinflammation contributes to disease progression. Secondly, we are examining how neuroinflammatory responses contribute to long-term decline, particularly with regard to cognitive function and following multiple traumatic events.
- Bu W, Ren H, Deng Y, Del Mar N, Guley NM, Moore BM, Honig MG, Reiner A. Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist. Front Neurosci. 2016 Oct 6;10:449. eCollection 2016. PubMed PMID: 27766068; PubMed Central PMCID: PMC5052277.
- Guley NH, Rogers JT, Del Mar NA, Deng Y, Islam RM, D'Surney L, Ferrell J, Deng B, Hines-Beard J, Bu W, Ren H, Elberger AJ, Marchetta JG, Rex TS, Honig MG, Reiner A. A Novel Closed-Head Model of Mild Traumatic Brain Injury Using Focal Primary Overpressure Blast to the Cranium in Mice. J Neurotrauma. 2016 Feb 15;33(4):403-22. doi: 10.1089/neu.2015.3886. Epub 2015 Dec 17. PubMed PMID: 26414413; PubMed Central PMCID: PMC4761824.
- del Mar N, von Buttlar X, Yu AS, Guley NH, Reiner A, Honig MG. A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments. Exp Neurol. 2015 Sep;271:53-71. doi: 10.1016/j.expneurol.2015.04.023. Epub 2015 May 7. PubMed PMID: 25957630; PubMed Central PMCID: PMC4586366.
- Reiner A, Heldt SA, Presley CS, Guley NH, Elberger AJ, Deng Y, D'Surney L, Rogers JT, Ferrell J, Bu W, Del Mar N, Honig MG, Gurley SN, Moore BM 2nd. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. Int J Mol Sci. 2014 Dec 31;16(1):758-87. doi: 10.3390/ijms16010758. PubMed PMID: 25561230; PubMed Central PMCID: PMC4307274.
- Heldt SA, Elberger AJ, Deng Y, Guley NH, Del Mar N, Rogers J, Choi GW, Ferrell J, Rex TS, Honig MG, Reiner A. A novel closed-head model of mild traumatic brain injury caused by primary overpressure blast to the cranium produces sustained emotional deficits in mice. Front Neurol. 2014 Jan 22;5:2. doi: 10.3389/fneur.2014.00002. eCollection 2014. PubMed PMID: 24478749; PubMed Central PMCID: PMC3898331.
- Cagle MC, Honig MG. Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord. J Comp Neurol. 2014 Feb 1;522(2):479-97. doi: 10.1002/cne.23422. PubMed PMID: 23853053; PubMed Central PMCID: PMC3855892.