J. Paul Taylor, M.D., Ph.D.

J. Paul Taylor, M.D., Ph.D.

Adjunct Member/Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center


Primary Appointment: St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6047
Fax: (901) 595-5947
Email: J. Paul Taylor



Education

  • M.D./Ph.D. Institution: Jefferson Medical College, Philadelphia, PA
  • Neurology Residency: Hospital of the University of Pennsylvania
  • Neurogenetics Fellowship: Neurogenetics Branch, NINDS/NIH

Link

Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
  • Screen small molecules to identify compounds that can be translated to clinical use

Representative Publications

  • Gao FB, Taylor JP. RNA metabolism in neurological disease. Brain Res. 2014 Oct 10;1584:1-2. doi: 10.1016/j.brainres.2014.09.011. PubMed PMID: 25248315; PubMed Central PMCID: PMC4196277.
  • Figley MD, Bieri G, Kolaitis RM, Taylor JP, Gitler AD. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. J Neurosci. 2014 Jun 11;34(24):8083-97. doi: 10.1523/JNEUROSCI.0543-14.2014. PubMed PMID: 24920614; PubMed Central PMCID: PMC4051967.
  • He F, Krans A, Freibaum BD, Taylor JP, Todd PK. TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1. Hum Mol Genet. 2014 Oct 1;23(19):5036-51. doi: 10.1093/hmg/ddu216. Epub 2014 May 8. PubMed PMID: 24920338; PubMed Central PMCID: PMC4159148.
  • Pinkus JL, Amato AA, Taylor JP, Greenberg SA. Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis. Neuromuscul Disord. 2014 Jul;24(7):611-6. doi: 10.1016/j.nmd.2014.04.012. Epub 2014 May 6. PubMed PMID: 24857366.
  • Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD; ITALSGEN Consortium, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, ChiĆ² A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014 May;17(5):664-6. doi: 10.1038/nn.3688. Epub 2014 Mar 30. PubMed PMID: 24686783; PubMed Central PMCID: PMC4000579.
  • Seelen M, Visser AE, Overste DJ, Kim HJ, Palud A, Wong TH, van Swieten JC, Scheltens P, Voermans NC, Baas F, de Jong JM, van der Kooi AJ, de Visser M, Veldink JH, Taylor JP, Van Es MA, van den Berg LH. No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Neurobiol Aging. 2014 Aug;35(8):1956.e9-1956.e11. doi: 10.1016/j.neurobiolaging.2014.01.152. Epub 2014 Feb 6. PubMed PMID: 24612671.

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