J. Paul Taylor, M.D., Ph.D.

J. Paul Taylor, M.D., Ph.D.

Adjunct Member/Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center


Primary Appointment: St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6047
Fax: (901) 595-5947
Email: J. Paul Taylor



Education

  • M.D./Ph.D. Institution: Jefferson Medical College, Philadelphia, PA
  • Neurology Residency: Hospital of the University of Pennsylvania
  • Neurogenetics Fellowship: Neurogenetics Branch, NINDS/NIH

Link

Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
  • Screen small molecules to identify compounds that can be translated to clinical use

Representative Publications

  • Sanhueza M, Chai A, Smith C, McCray BA, Simpson TI, Taylor JP, Pennetta G. Network Analyses Reveal Novel Aspects of ALS Pathogenesis. PLoS Genet. 2015 Mar 31;11(3):e1005107. doi: 10.1371/journal.pgen.1005107. eCollection 2015 Feb. PubMed PMID: 25826266; PubMed Central PMCID: PMC4380362.
  • Scoto M, Rossor AM, Harms MB, Cirak S, Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A, Mansour S, Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, Overweg-Plandsoen WC, Baas F, Taylor JP, Benatar M, Connolly AM, Al-Lozi MT, Nixon J, de Goede CG, Foley AR, Mcwilliam C, Pitt M, Sewry C, Phadke R, Hafezparast M, Chong WK, Mercuri E, Baloh RH, Reilly MM, Muntoni F. Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology. 2015 Feb 17;84(7):668-79. doi: 10.1212/WNL.0000000000001269. Epub 2015 Jan 21. PubMed PMID: 25609763; PubMed Central PMCID: PMC4336105.
  • Scaramuzzino C, Casci I, Parodi S, Lievens PM, Polanco MJ, Milioto C, Chivet M, Monaghan J, Mishra A, Badders N, Aggarwal T, Grunseich C, Sambataro F, Basso M, Fackelmayer FO, Taylor JP, Pandey UB, Pennuto M. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Neuron. 2015 Jan 7;85(1):88-100. doi: 10.1016/j.neuron.2014.12.031. PubMed PMID: 25569348; PubMed Central PMCID: PMC4305189.
  • Lee JY, Kapur M, Li M, Choi MC, Choi S, Kim HJ, Kim I, Lee E, Taylor JP, Yao TP. MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria. J Cell Sci. 2014 Nov 15;127(22):4954-63. doi: 10.1242/jcs.157321. Epub 2014 Sep 30. PubMed PMID: 25271058; PubMed Central PMCID: PMC4231308.
  • Gao FB, Taylor JP. RNA metabolism in neurological disease. Brain Res. 2014 Oct 10;1584:1-2. doi: 10.1016/j.brainres.2014.09.011. PubMed PMID: 25248315; PubMed Central PMCID: PMC4196277.
  • Figley MD, Bieri G, Kolaitis RM, Taylor JP, Gitler AD. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. J Neurosci. 2014 Jun 11;34(24):8083-97. doi: 10.1523/JNEUROSCI.0543-14.2014. PubMed PMID: 24920614; PubMed Central PMCID: PMC4051967.

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