J. Paul Taylor, M.D., Ph.D.

J. Paul Taylor, M.D., Ph.D.

Adjunct Member/Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center

Primary Appointment: St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6047
Fax: (901) 595-5947
Email: J. Paul Taylor


  • M.D./Ph.D. Institution: Jefferson Medical College, Philadelphia, PA
  • Neurology Residency: Hospital of the University of Pennsylvania
  • Neurogenetics Fellowship: Neurogenetics Branch, NINDS/NIH


Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
  • Screen small molecules to identify compounds that can be translated to clinical use

Representative Publications

  • Molliex A, Temirov J, Lee J, Coughlin M, Kanagaraj AP, Kim HJ, Mittag T, Taylor JP. Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization. Cell. 2015 Sep 24;163(1):123-33. doi: 10.1016/j.cell.2015.09.015. PubMed PMID: 26406374.
  • Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, Zarnescu DC. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Hum Mol Genet. 2015 Dec 15;24(24):6886-98. doi: 10.1093/hmg/ddv389. Epub 2015 Sep 18. PubMed PMID: 26385636.
  • Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 2015 Sep 3;525(7567):129-33. doi: 10.1038/nature14974. Epub 2015 Aug 26. PubMed PMID: 26308899; PubMed Central PMCID: PMC4631399.
  • Taylor JP. Multisystem proteinopathy: intersecting genetics in muscle, bone, and brain degeneration. Neurology. 2015 Aug 25;85(8):658-60. doi: 10.1212/WNL.0000000000001862. Epub 2015 Jul 24. PubMed PMID: 26208960.
  • Oh SY, He F, Krans A, Frazer M, Taylor JP, Paulson HL, Todd PK. RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Hum Mol Genet. 2015 Aug 1;24(15):4317-26. doi: 10.1093/hmg/ddv165. Epub 2015 May 7. PubMed PMID: 25954027; PubMed Central PMCID: PMC4492395.
  • Norris KL, Hao R, Chen LF, Lai CH, Kapur M, Shaughnessy PJ, Chou D, Yan J, Taylor JP, Engelender S, West AE, Lim KL, Yao TP. Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. J Biol Chem. 2015 May 29;290(22):13862-74. doi: 10.1074/jbc.M114.634063. Epub 2015 Apr 10. PubMed PMID: 25861987; PubMed Central PMCID: PMC4447961.

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