J. Paul Taylor, M.D., Ph.D.

J. Paul Taylor, M.D., Ph.D.

Adjunct Member/Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center


Primary Appointment: St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Phone: (901) 595-6047
Fax: (901) 595-5947
Email: J. Paul Taylor



Education

  • M.D./Ph.D. Institution: Jefferson Medical College, Philadelphia, PA
  • Neurology Residency: Hospital of the University of Pennsylvania
  • Neurogenetics Fellowship: Neurogenetics Branch, NINDS/NIH

Link

Research Interests

The principal goal of our research is to reduce the morbidity and mortality associated with neurological disease. Toward this end we:

  • Use in vitro and in vivo modeling to elucidate the molecular basis of neuronal dysfunction and neuronal loss in neurological diseases
  • Use the fruit fly Drosophila melanogaster to apply the power of genetics to illuminate the pathogenesis of neurodegeneration
  • Investigate the molecular genetics of amyotrophic lateral sclerosis, frontotemporal dementia, inclusion body myopathy and polyglutamine disease
  • Screen small molecules to identify compounds that can be translated to clinical use

Representative Publications

  • Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, Pittman A, Orrell RW, Malaspina A, Sidle KC, Fratta P, Harms MB, Baloh RH, Pestronk A, Weihl CC, Rogaeva E, Zinman L, Drory VE, Borghero G, Mora G, Calvo A, Rothstein JD; ITALSGEN, Drepper C, Sendtner M, Singleton AB, Taylor JP, Cookson MR, Restagno G, Sabatelli M, Bowser R, ChiĆ² A, Traynor BJ. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nat Neurosci. 2014 Mar 30. doi: 10.1038/nn.3688. [Epub ahead of print] PubMed PMID: 24686783.
  • Seelen M, Visser AE, Overste DJ, Kim HJ, Palud A, Wong TH, van Swieten JC, Scheltens P, Voermans NC, Baas F, de Jong JM, van der Kooi AJ, de Visser M, Veldink JH, Taylor JP, Van Es MA, van den Berg LH. No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy. Neurobiol Aging. 2014 Feb 6. pii: S0197-4580(14)00177-8. doi: 10.1016/j.neurobiolaging.2014.01.152. [Epub ahead of print] PubMed PMID: 24612671.
  • Taylor JP. Neurodegenerative diseases: G-quadruplex poses quadruple threat. Nature. 2014 Mar 13;507(7491):175-7. doi: 10.1038/nature13067. Epub 2014 Mar 5. PubMed PMID: 24598546.
  • Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, Shaw CE, Eggan KC, Maniatis T, Taylor JP. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 2014 Feb 5;81(3):536-43. doi: 10.1016/j.neuron.2013.12.018. PubMed PMID: 24507191; PubMed Central PMCID: PMC3939050.
  • Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron. 2013 Apr 10;78(1):65-80. doi: 10.1016/j.neuron.2013.02.029. Epub 2013 Mar 14. Erratum in: Neuron. 2013 Apr 24;78(2):403. PubMed PMID: 23498974; PubMed Central PMCID: PMC3683300.
  • Taylor JP. Neuroscience. RNA that gets RAN in neurodegeneration. Science. 2013 Mar 15;339(6125):1282-3. doi: 10.1126/science.1236450. PubMed PMID: 23493702.

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