Jena J. Steinle, Ph.D.

Jena J. Steinle, Ph.D.

Associate Professor
Department of Ophthalmology
Department of Anatomy and Neurobiology
Hamilton Eye Institute


The University of Tennessee Health Science Center
930 Madison Ave, Suite 768A
Memphis, TN 38163
Tel: (901) 448-1910
Fax: (901) 448-5028
Email: Jena J. Steinle



Education

  • Ph.D. Institution: University of Kansas Medical Center, Kansas City, KS
  • Postdoctoral: Texas A&M University Health Science Center, Temple, TX

Links

Ophthalmology - Jena Steinle

Research Interests

Research in our lab investigates changes in the choroid and retina in age-related macular degeneration and diabetic retinopathy. We are currently working on the effects of loss in sympathetic innervation (the fight or flight system) on the retinal pathology associated with diabetic retinopathy and choroidal pathology with macular degeneration. We use modern cellular and molecular biology techniques on cell culture and animal samples to evaulate the mechanisms for the disease processes. We are also interested in the interactions between sympathetic nerves and the vasculature they innervate.

Representative Publications

  • Jiang Y, Biswas SK, Steinle JJ. Serine 307 on insulin receptor substrate 1 is required for SOCS3 and TNF-╬▒ signaling in the rMC-1 cell line. Mol Vis. 2014 Oct 23;20:1463-70. eCollection 2014. PubMed PMID: 25352752; PubMed Central PMCID: PMC4207855.
  • Jiang Y, Zhang Q, Ye EA, Steinle JJ. Etanercept restores normal insulin signal transduction in ╬▓2-adrenergic receptor knockout mice. J Neuroinflammation. 2014 Aug 20;11:137. doi: 10.1186/s12974-014-0137-z. PubMed PMID: 25138272; PubMed Central PMCID: PMC4149274.
  • Zhang Q, Steinle JJ. IGFBP-3 inhibits TNF-╬▒ production and TNFR-2 signaling to protect against Retinal Endothelial Cell Apoptosis. Microvasc Res. 2014 Sep;95:76-81. doi: 10.1016/j.mvr.2014.07.009. Epub 2014 Jul 30. PubMed PMID: 25086184.
  • Jiang Y, Thakran S, Bheemreddy R, Ye EA, He H, Walker RJ, Steinle JJ. Pioglitazone normalizes insulin signaling in the diabetic rat retina through reduction in tumor necrosis factor ╬▒ and suppressor of cytokine signaling 3. J Biol Chem. 2014 Sep 19;289(38):26395-405. doi: 10.1074/jbc.M114.583880. Epub 2014 Aug 1. PubMed PMID: 25086044; PubMed Central PMCID: PMC4176235.
  • Jiang Y, Pagadala J, Miller DD, Steinle JJ. Insulin-like growth factor-1 binding protein 3 (IGFBP-3) promotes recovery from trauma-induced expression of inflammatory and apoptotic factors in retina. Cytokine. 2014 Dec;70(2):115-9. doi: 10.1016/j.cyto.2014.07.004. Epub 2014 Jul 28. PubMed PMID: 25082650.
  • Zhang Q, Soderland D, Steinle JJ. TNF╬▒ inhibits IGFBP-3 through activation of p38╬▒ and casein kinase 2 in human retinal endothelial cells. PLoS One. 2014 Jul 29;9(7):e103578. doi: 10.1371/journal.pone.0103578. eCollection 2014. PubMed PMID: 25073020; PubMed Central PMCID: PMC4114743.

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