Jena J. Steinle, Ph.D.

Jena J. Steinle, Ph.D.

Associate Professor
Department of Ophthalmology
Department of Anatomy and Neurobiology
Hamilton Eye Institute


The University of Tennessee Health Science Center
930 Madison Ave, Suite 768A
Memphis, TN 38163
Tel: (901) 448-1910
Fax: (901) 448-5028
Email: Jena J. Steinle



Education

  • Ph.D. Institution: University of Kansas Medical Center, Kansas City, KS
  • Postdoctoral: Texas A&M University Health Science Center, Temple, TX

Links

Ophthalmology - Jena Steinle

Research Interests

Research in our lab investigates changes in the choroid and retina in age-related macular degeneration and diabetic retinopathy. We are currently working on the effects of loss in sympathetic innervation (the fight or flight system) on the retinal pathology associated with diabetic retinopathy and choroidal pathology with macular degeneration. We use modern cellular and molecular biology techniques on cell culture and animal samples to evaulate the mechanisms for the disease processes. We are also interested in the interactions between sympathetic nerves and the vasculature they innervate.

Representative Publications

  • Tse BC, Steinle JJ, Johnson D, Haik BG, Wilson MW. Superselective Intraophthalmic Artery Chemotherapy in a Nonhuman Primate Model: Histopathologic Findings. JAMA Ophthalmol. 2013 Apr 25:1-8. doi: 10.1001/jamaophthalmol.2013.2065. [Epub ahead of print] PubMed PMID: 23619956.
  • Jiang Y, Pagadala J, Miller D, Steinle JJ. Reduced insulin receptor signaling in retinal Müller cells cultured in high glucose. Mol Vis. 2013 Apr 5;19:804-11. Print 2013. PubMed PMID: 23592917; PubMed Central PMCID: PMC3626298.
  • Zhang Q, Jiang Y, Toutounchian JJ, Soderland C, Yates CR, Steinle JJ. Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions. Mol Vis. 2013 Apr 5;19:796-803. Print 2013. PubMed PMID: 23592916; PubMed Central PMCID: PMC3626378.
  • Zhang Q, Steinle JJ. DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose. Invest Ophthalmol Vis Sci. 2013 Apr 30;54(4):3052-7. doi: 10.1167/iovs.12-11533. PubMed PMID: 23557743; PubMed Central PMCID: PMC3640744.
  • Zhang Q, Soderland C, Steinle JJ. Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor. Apoptosis. 2013 Mar;18(3):361-8. doi: 10.1007/s10495-012-0793-3. PubMed PMID: 23291901.
  • Steinle JJ. Retinal endothelial cell apoptosis. Apoptosis. 2012 Dec;17(12):1258-60. doi: 10.1007/s10495-012-0777-3. PubMed PMID: 23143137.

View more references (pubmed link)