Joseph C. Callaway, Ph.D.

Joseph C. Callaway, Ph.D.

Professor
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-8497
Fax: (901) 448-7193
Lab: 221 Wittenborg Anatomy Building
Email: Joseph C. Callaway



Education

  • Ph.D. Institution: University of Washington, Seattle
  • Postdoctoral: University of North Carolina, Chapel Hill; New York Medical College, Valhalla, NY

Research Interests

Research is focused on the integration of synaptic inputs in the dendrites of individual CNS neurons, the regional properties of neurons, the interaction between pairs of synaptically connected neurons, and the plasticity of synaptic inputs.

Studies are conducted mainly on thin slice preparations of rat cerebellum though identifiable neurons in slice preparations of other parts of the brain are also utilized. Concurrent whole cell patch electrophysiology and high-speed fluorescence imaging is used to measure signals throughout the dendrites of individual neurons. Imaging studies focus on calcium and sodium ion changes in the soma and dendrites of cerebellar Purkinje cells. Voltage sensitive dyes are also used to access the spatial extent of synaptic inputs. Synaptic inputs are activated by extracellular stimulus of appropriate axons or by simultaneous recording of a presynaptic neuron. The laboratory is equipped to visually patch one or more neurons on the surface of a thin slice using DIC optics. Imaging of calcium transients while recording potentials from synaptic inputs is used to examine the effects of local dendritic integration on the amplitude and extent of calcium elevation in the dendrites and to determine the contribution of this calcium to long term depression of excitatory synaptic inputs in Purkinje cells.

Representative Publications

  • Schile LM, Callaway JC, Morris JT, Stralberg D, Parker VT, Kelly M. Modeling tidal marsh distribution with sea-level rise: evaluating the role of vegetation, sediment, and upland habitat in marsh resiliency. PLoS One. 2014 Feb 13;9(2):e88760. doi: 10.1371/journal.pone.0088760. eCollection 2014. PubMed PMID: 24551156; PubMed Central PMCID: PMC3923833.
  • Kärkkäinen OK, Lehtonen M, Laukkanen V, Tupala E, Hyytiä P, Kautiainen H, Tiihonen J, Callaway JC, Storvik M. Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics. Alcohol. 2013 Aug;47(5):399-403. doi: 10.1016/j.alcohol.2013.05.003. Epub 2013 Jun 6. PubMed PMID: 23747173.
  • Stralberg D, Brennan M, Callaway JC, Wood JK, Schile LM, Jongsomjit D, Kelly M, Parker VT, Crooks S. Evaluating tidal marsh sustainability in the face of sea-level rise: a hybrid modeling approach applied to San Francisco Bay. PLoS One. 2011;6(11):e27388. doi: 10.1371/journal.pone.0027388. Epub 2011 Nov 16. PubMed PMID: 22110638; PubMed Central PMCID: PMC3217990.
  • Doherty JM, Callaway JC, Zedler JB. Diversity-function relationships changed in a long-term restoration experiment. Ecol Appl. 2011 Sep;21(6):2143-55. PubMed PMID: 21939050.
  • Aarnio V, Lehtonen M, Storvik M, Callaway JC, Lakso M, Wong G. Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family. Front Pharmacol. 2011 Mar 18;2:12. doi: 10.3389/fphar.2011.00012. eCollection 2011. PubMed PMID: 21687507; PubMed Central PMCID: PMC3108558.
  • Lehtonen M, Storvik M, Malinen H, Hyytiä P, Lakso M, Auriola S, Wong G, Callaway JC. Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 1;879(11-12):677-94. doi: 10.1016/j.jchromb.2011.02.004. Epub 2011 Feb 28. PubMed PMID: 21367677.

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