Joseph C. Callaway, Ph.D.
Department of Pediatrics
Department of Anatomy and Neurobiology
The University of Tennessee
Health Science Center
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-8497
Fax: (901) 448-7193
Lab: 221 Wittenborg Anatomy Building
Email: Joseph C. Callaway
- Ph.D. Institution: University of Washington, Seattle
- Postdoctoral: University of North Carolina, Chapel Hill; New York Medical College, Valhalla, NY
Research is focused on the integration of synaptic inputs in the dendrites of individual CNS neurons, the regional properties of neurons, the interaction between pairs of synaptically connected neurons, and the plasticity of synaptic inputs.
Studies are conducted mainly on thin slice preparations of rat cerebellum though identifiable neurons in slice preparations of other parts of the brain are also utilized. Concurrent whole cell patch electrophysiology and high-speed fluorescence imaging is used to measure signals throughout the dendrites of individual neurons. Imaging studies focus on calcium and sodium ion changes in the soma and dendrites of cerebellar Purkinje cells. Voltage sensitive dyes are also used to access the spatial extent of synaptic inputs. Synaptic inputs are activated by extracellular stimulus of appropriate axons or by simultaneous recording of a presynaptic neuron. The laboratory is equipped to visually patch one or more neurons on the surface of a thin slice using DIC optics. Imaging of calcium transients while recording potentials from synaptic inputs is used to examine the effects of local dendritic integration on the amplitude and extent of calcium elevation in the dendrites and to determine the contribution of this calcium to long term depression of excitatory synaptic inputs in Purkinje cells.
- Dong HW, Hayar A, Callaway J, Yang XH, Nai Q, Ennis M. Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. J Neurosci. 2009 Sep 23;29(38):11943-53. doi: 10.1523/JNEUROSCI.0206-09.2009. PubMed PMID: 19776280; PubMed Central PMCID: PMC3837548.
- Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD. Computational model predicts a role for ERG current in repolarizing plateau potentials in dopamine neurons: implications for modulation of neuronal activity. J Neurophysiol. 2007 Nov;98(5):3006-22. PubMed PMID: 17699694.
- Kalume F, Lee SM, Morcos Y, Callaway JC, Levin MC. Molecular mimicry: cross-reactive antibodies from patients with immune-mediated neurologic disease inhibit neuronal firing. J Neurosci Res. 2004 Jul 1;77(1):82-9. PubMed PMID: 15197740.
- Roper P, Callaway J, Armstrong W. Burst initiation and termination in phasic vasopressin cells of the rat supraoptic nucleus: a combined mathematical, electrical, and calcium fluorescence study. J Neurosci. 2004 May 19;24(20):4818-31. PubMed PMID: 15152042.
- Roper P, Callaway J, Shevchenko T, Teruyama R, Armstrong W. AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones. J Comput Neurosci. 2003 Nov-Dec;15(3):367-89. PubMed PMID: 14618071.
- Levin MC, Lee SM, Kalume F, Morcos Y, Dohan FC Jr, Hasty KA, Callaway JC, Zunt J, Desiderio D, Stuart JM. Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat Med. 2002 May;8(5):509-13. PubMed PMID: 11984596; PubMed Central PMCID: PMC2703733.