Department of Anatomy and Neurobiology
The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-1226
Fax: (901) 448-7193
Email: Hong-Wei Dong
- Ph.D. Institution: Department of Neurobiology, Health Research Science Center, Peking University, Beijing, China
- Postdoctoral: Washington University in St Louis, Department of Anatomy and Neurobiology; St Louis University, Department of Physiology and Pharmacology
Functional neural circuits in the brain involve a network of connected neurons, which process input and output information. The neural activity would be determined by the balance of synaptic excitation and inhibition. Any manipulations that shift the balance will change the output of the circuit. My research goal is to understand how the balance of excitation and inhibition within neuronal circuits is achieved, how it develops with experience, and how it changes in response to exogenous manipulations. I am currently investigating how various neurons interact and integrate chemical sensory information in the olfactory bulb circuits by employing neuroanatomical and neurophysiological approaches in brain slices.
- Dong HW, Davis JC, Ding S, Nai Q, Zhou FM, Ennis M. Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb. Neurosci Lett. 2012 Aug 22;524(1):49-54. doi: 10.1016/j.neulet.2012.07.013. Epub 2012 Jul 20. PubMed PMID: 22820212; PubMed Central PMCID: PMC3857022.
- Nai Q, Dong HW, Linster C, Ennis M. Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience. 2010 Aug 25;169(2):882-92. doi: 10.1016/j.neuroscience.2010.05.010. Epub 2010 May 11. PubMed PMID: 20466037; PubMed Central PMCID: PMC2904409.
- Dong HW, Hayar A, Callaway J, Yang XH, Nai Q, Ennis M. Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. J Neurosci. 2009 Sep 23;29(38):11943-53. doi: 10.1523/JNEUROSCI.0206-09.2009. PubMed PMID: 19776280; PubMed Central PMCID: PMC3837548.
- Dong HW, Heinbockel T, Hamilton KA, Hayar A, Ennis M. Metabotropic glutamate receptors and dendrodendritic synapses in the main olfactory bulb. Ann N Y Acad Sci. 2009 Jul;1170:224-38. doi: 10.1111/j.1749-6632.2009.03891.x. PubMed PMID: 19686141; PubMed Central PMCID: PMC2794417.
- Nai Q, Dong HW, Hayar A, Linster C, Ennis M. Noradrenergic regulation of GABAergic inhibition of main olfactory bulb mitral cells varies as a function of concentration and receptor subtype. J Neurophysiol. 2009 May;101(5):2472-84. doi: 10.1152/jn.91187.2008. Epub 2009 Mar 11. PubMed PMID: 19279145; PubMed Central PMCID: PMC2681435.
- Dong HW, Hayar A, Ennis M. Activation of group I metabotropic glutamate receptors on main olfactory bulb granule cells and periglomerular cells enhances synaptic inhibition of mitral cells. J Neurosci. 2007 May 23;27(21):5654-63. PubMed PMID: 17522310; PubMed Central PMCID: PMC2596473.