Hong-Wei Dong

Hong-Wei Dong, Ph.D.

Assistant Professor
Department of Anatomy and Neurobiology


The University of Tennessee Health Science Center
855 Monroe Avenue, Suite 515
Memphis, TN 38163
Phone: (901) 448-1226
Fax: (901) 448-7193
Email: Hong-Wei Dong


Education

  • Ph.D. Institution: Department of Neurobiology, Health Research Science Center, Peking University, Beijing, China
  • Postdoctoral: Washington University in St Louis, Department of Anatomy and Neurobiology; St Louis University, Department of Physiology and Pharmacology

Research Interests

Functional neural circuits in the brain involve a network of connected neurons, which process input and output information. The neural activity would be determined by the balance of synaptic excitation and inhibition. Any manipulations that shift the balance will change the output of the circuit. My research goal is to understand how the balance of excitation and inhibition within neuronal circuits is achieved, how it develops with experience, and how it changes in response to exogenous manipulations. I am currently investigating how various neurons interact and integrate chemical sensory information in the olfactory bulb circuits by employing neuroanatomical and neurophysiological approaches in brain slices.

Representative Publications

  • Dong HW, Ennis M. Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells. Front Cell Neurosci. 2018 Jan 17;11:436. doi: 10.3389/fncel.2017.00436. eCollection 2017. PubMed PMID: 29386998; PubMed Central PMCID: PMC5776129.
  • Zhou FW, Dong HW, Ennis M. Activation of β-noradrenergic receptors enhances rhythmic bursting in mouse olfactory bulb external tufted cells. J Neurophysiol. 2016 Dec 1;116(6):2604-2614. doi: 10.1152/jn.00034.2016. Epub 2016 Sep 14. PubMed PMID: 27628203; PubMed Central PMCID: PMC5133314.
  • Dong HW, Ennis M. Activation of group I metabotropic glutamate receptors enhances persistent sodium current and rhythmic bursting in main olfactory bulb external tufted cells. J Neurophysiol. 2014 Feb;111(3):641-7. doi: 10.1152/jn.00696.2013. Epub 2013 Nov 13. PubMed PMID: 24225539; PubMed Central PMCID: PMC3921410.
  • Dong HW, Davis JC, Ding S, Nai Q, Zhou FM, Ennis M. Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb. Neurosci Lett. 2012 Aug 22;524(1):49-54. doi: 10.1016/j.neulet.2012.07.013. Epub 2012 Jul 20. PubMed PMID: 22820212; PubMed Central PMCID: PMC3857022.
  • Nai Q, Dong HW, Linster C, Ennis M. Activation of alpha1 and alpha2 noradrenergic receptors exert opposing effects on excitability of main olfactory bulb granule cells. Neuroscience. 2010 Aug 25;169(2):882-92. doi: 10.1016/j.neuroscience.2010.05.010. Epub 2010 May 11. PubMed PMID: 20466037; PubMed Central PMCID: PMC2904409.
  • Dong HW, Hayar A, Callaway J, Yang XH, Nai Q, Ennis M. Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. J Neurosci. 2009 Sep 23;29(38):11943-53. doi: 10.1523/JNEUROSCI.0206-09.2009. PubMed PMID: 19776280; PubMed Central PMCID: PMC3837548.

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