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EDWARD CHAUM, M.D., Ph.D.
- Plough Foundation Professor of Retinal Diseases
Professor
- Department of Ophthalmology
- Department of Pediatrics
- Department of Anatomy and Neurobiology
- Department of Biomedical Engineering
- The University of Tennessee Health Science Center
Address
- The University of Tennessee Health Science Center
- Hamilton Eye Institute
- 930 Madison Avenue, Suite 731
- Memphis, TN 38163
- Tel: (901) 448-5975;
Education
- Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
- M.D. Institution: Cornell University Medical College
Research Interests
The focus of the basic science research program in our laboratory is in five major areas:
- Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
- Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
- Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
- Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
- Tele-ophthalmology and automated diagnostics
Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:
- Genomic analysis of RPE gene expression,
- The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
- The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
- Electrochemical quantification of blood metabolites and drugs, and
- Nanotechnology applications in retinal surgery, and
- Clinical research studies.
Links
- Ophthalmology - Edward Chaum
Recent Publications
- Giddabasappa A, Bauler MN, Yepuru M, Chaum E, Dalton JT, Eswaraka JR.
17-{beta} Estradiol protects ARPE-19 cells from oxidative stress through
estrogen receptor-{beta}
Invest Ophthalmol Vis Sci. 2010 May 12; [Epub ahead of print]
PMID: 20463317
- Spentzas T, Henricksen J, Patters AB, Chaum E.
Correlation of intraocular pressure with intracranial pressure in children with
severe head injuries.
Pediatr Crit Care Med. 2010 Jan 14; [Epub ahead of print]
PMID: 20081553
- Karnowski TP, Aykac D, Chaum E, Giancardo L, Li Y, Tobin KW Jr, Abramoff MD.
Practical considerations for optic nerve location in telemedicine.
Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6205-9.
PMID: 19965082
- Chaum E, Yin J, Yang H, Thomas F, Lang JC.
Quantitative AP-1 gene regulation by oxidative stress in the human retinal
pigment epithelium.
J Cell Biochem. 2009 Dec 15;108(6):1280-91.
PMID: 19795388
- Diabetes Control and Complications Trial/Epidemiology of Diabetes
Interventions and Complications (DCCT/EDIC) Research Group; Nathan DM, Zinman B,
Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ.
Modern-day clinical course of type 1 diabetes mellitus after 30 years'
duration: the diabetes control and complications trial/epidemiology of diabetes
interventions and complications and Pittsburgh epidemiology of diabetes
complications experience (1983-2005).
Arch Intern Med. 2009 Jul 27;169(14):1307-16.
PMID: 19636033
- Tobin KW, Abramoff MD, Chaum E, Giancardo L, Govindasamy V, Karnowski TP,
Tennant MT, Swainson S.
Using a patient image archive to diagnose retinopathy.
Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5441-4.
PMID: 19163948
view complete list of references (pubmed link)
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