Edward Chaum, M.D., Ph.D.


Edward Chaum, M.D., Ph.D.

Acting Director of Research

Plough Foundation Professor of Retinal Diseases
Hamilton Eye Institute
Department of Ophthalmology


Department of Pediatrics
Department of Anatomy and Neurobiology
Department of Biomedical Engineering


The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Avenue, Suite 731
Memphis, TN 38163
Tel: (901) 448-5975
Email: Edward Chaum

 

Education

  • Ph.D. Institution: Department of Cell Biology and Genetics, Cornell Graduate School of Medical Sciences
  • M.D. Institution: Cornell University Medical College

Link

Ophthalmology - Edward Chaum

Research Interests

The focus of the basic science research program in our laboratory is in five major areas:

  • Translational research in the development and application of gene therapy to the treatment of retina degenerative diseases,
  • Tissue engineering approaches to understanding and modulating the growth, aging and wound healing responses of ocular retinal pigment epithelial cells (RPE),
  • Molecular analyses of retinal pigment epithelial cell responses to oxidative stress,
  • Characterization of a newly discovered IGF binding protein regulatory system in the RPE, and
  • Tele-ophthalmology and automated diagnostics

Other areas of active research include collaborations on numerous pilot basic science and clinical projects with investigations into:

  • Genomic analysis of RPE gene expression,
  • The role of CD81 in proliferative vitreoretinopathy, wound healing and retinal detachment,
  • The role of Arf gene mutations in the developmental eye anomaly persistent fetal vasculature,
  • Electrochemical quantification of blood metabolites and drugs, and
  • Nanotechnology applications in retinal surgery, and
  • Clinical research studies.

Representative Publications

  • Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162. PubMed PMID: 28437526; PubMed Central PMCID: PMC5403116.
  • DCCT/EDIC Research Group, Nathan DM, Bebu I, Hainsworth D, Klein R, Tamborlane W, Lorenzi G, Gubitosi-Klug R, Lachin JM. Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes. N Engl J Med. 2017 Apr 20;376(16):1507-1516. doi: 10.1056/NEJMoa1612836. PubMed PMID: 28423305.
  • Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J. Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells. J Cancer. 2017 Jan 1;8(1):57-64. doi: 10.7150/jca.16723. eCollection 2017. PubMed PMID: 28123598; PubMed Central PMCID: PMC5264040.
  • Toutounchian JJ, Pagadala J, Miller DD, Baudry J, Park F, Chaum E, Yates CR. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91(1):1-13. Epub 2016 Nov 9. PubMed PMID: 27913654.
  • Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group, Natarajan R. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9. PubMed PMID: 27162351; PubMed Central PMCID: PMC4890596.
  • Lenherr SM, Clemens JQ, Braffett BH, Cleary PA, Dunn RL, Hotaling JM, Jacobson AM, Kim C, Herman W, Brown JS, Wessells H, Sarma AV; DCCT/EDIC Research Group. Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC. J Urol. 2016 Oct;196(4):1129-35. doi: 10.1016/j.juro.2016.04.071. Epub 2016 Apr 27. PubMed PMID: 27131462; PubMed Central PMCID: PMC5025347.

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