Charles W. Leffler, Ph.D.

Charles W. Leffler, Ph.D.

Department of Physiology
Department of Pediatrics

The University of Tennessee Health Science Center
309 Nash Research Building
894 Union Avenue
Memphis, TN 38163
Phone: (901) 448-7122;
Fax: (901) 448-7126
Email: Charles W. Leffler


  • Ph.D. Institution: University of Florida, Department of Zoology
  • Postdoctoral: University of Florida, Department of Physiology


Physiology - Charles Leffler

Research Interests

Research in the laboratory concentrates on control of newborn cerebral circulation. A focus of this research is control of the newborn cerebral microvasculature during physiological and pathological situations, and the cellular mechanisms involved in such control. We investigate autocrine and paracrine communication within the neurovascular unit, with specific current focus on two novel, endogenously produced, gaseous transmitter molecules, carbon monoxide (CO) and hydrogen sulfide (H2S). This research is important because the single most prominent cause of mortality and morbidity in newborns is hypoxic-ischemic brain injury, which often leads to lifelong disability in survivors. The neonatal brain is more susceptible to injury from insufficient or inappropriate blood flow for metabolism than that of the adult because of rapid development and proliferation of neurons and vessels, and high susceptibility to inflammation. Successes in developing approaches to avert and treat perinatal hypoxia-ischemic brain damage have been limited by insufficient understanding of the mechanisms that control perinatal cerebral circulation. The gasotransmitters, CO and H2S, are mechanisms of which greater understanding is urgently needed.

Representative Publications