Alessandro Iannaccone, M.D., M.S.
Director
Retinal Degeneration & Ophthalmic
Genetics Service
Director
Lions Visual Function Diagnostic Lab
Department of Ophthalmology
The University of Tennessee Health
Science Center
The University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Ave, Suite 731 (academic)
930 Madison Ave, Suite 400 (clinical)
Memphis, TN 38163 (USA)
Phone: (901) 448-7831 (academic)
(901) 448-6445/6185 (lab)
(901) 448-1241 (UTMG front desk)
Fax: (901) 448-5028 (UT)/1021 (UTMG)
Email: Alessandro Iannaccone
Grants Quick Links
Education
- M.D. Institution: University La Sapienza, School of Medicine, Rome, Italy
- M.S. Institution: (Epidemiology) College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN
- Postdoctoral: (Medical Retina Research) Scheie Eye Institute, University of Pennsylvania, Philadelphia; (Pediatric Retinal and Optic Nerve Diseases) University of Tennessee Health Science Center, Memphis
- Residency: School of Ophthalmology, Institute of Ophthalmology, University of Rome, Italy
Links
- Nominated as a recipient of the 2012 Research to Prevent Blindness Physician Scientist Award
- Ophthalmology - Alessandro Iannaccone
Research Interests
Presently, stronger emphasis in my research is on 1) inflammatory and autoimmune aspects of age related macular degeneration and panretinal retinopathies; 2) hereditary retinal diseases such as X-linked and dominant retinitis pigmentosa (RP), Leber's congenital amaurosis, Usher syndrome (RP with hearing loss) and Bardet-Biedl syndrome (RP with obesity, polydactyly, and other systemic manifestations); and 3) nutritional influences on macular function and macular pigment.
Recent Publications
- Branham K, Othman M, Brumm M, Karoukis AJ, Atmaca-Sonmez P, Yashar BM, Schwartz SB, Stover NB, Trzupek K, Wheaton D, Jennings B, Ciccarelli ML, Jayasundera KT, Lewis RA, Birch D, Bennett J, Sieving PA, Andreasson S, Duncan JL, Fishman GA, Iannaccone A, Weleber RG, Jacobson SG, Heckenlively JR, Swaroop A. Mutations in RPGR and RP2 account for 15% of males with simplex retinal degenerative disease. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8232-7. doi: 10.1167/iovs.12-11025. PubMed PMID: 23150612; PubMed Central PMCID: PMC3522443.
- Cox KF, Kerr NC, Kedrov M, Nishimura D, Jennings BJ, Stone EM, Sheffield VC, Iannaccone A. Phenotypic expression of Bardet-Biedl syndrome in patients homozygous for the common M390R mutation in the BBS1 gene. Vision Res. 2012 Dec 15;75:77-87. doi: 10.1016/j.visres.2012.08.005. Epub 2012 Aug 24. PubMed PMID: 22940089.
- Carboni G, Forma G, Bond AD, Adamus G, Iannaccone A. Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: a differential diagnostic challenge in a patient with unexplained visual loss. Doc Ophthalmol. 2012 Aug;125(1):63-70. doi: 10.1007/s10633-012-9327-0. Epub 2012 May 9. PubMed PMID: 22569848; PubMed Central PMCID: PMC3491897.
- Iannaccone A, Neeli I, Krishnamurthy P, Lenchik NI, Wan H, Gerling IC, Desiderio DM, Radic MZ. Autoimmune biomarkers in age-related macular degeneration: a possible role player in disease development and progression. Adv Exp Med Biol. 2012;723:11-6. doi: 10.1007/978-1-4614-0631-0_2. Review. PubMed PMID: 22183309.
- Jacobson SG, Cideciyan AV, Ratnakaram R, Heon E, Schwartz SB, Roman AJ, Peden MC, Aleman TS, Boye SL, Sumaroka A, Conlon TJ, Calcedo R, Pang JJ, Erger KE, Olivares MB, Mullins CL, Swider M, Kaushal S, Feuer WJ, Iannaccone A, Fishman GA, Stone EM, Byrne BJ, Hauswirth WW. Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years. Arch Ophthalmol. 2012 Jan;130(1):9-24. doi: 10.1001/archophthalmol.2011.298. Epub 2011 Sep 12. PubMed PMID: 21911650; PubMed Central PMCID: PMC3600816.
- Adamus G, Brown L, Schiffman J, Iannaccone A. Diversity in autoimmunity against retinal, neuronal, and axonal antigens in acquired neuro-retinopathy. J Ophthalmic Inflamm Infect. 2011 Sep;1(3):111-21. doi: 10.1007/s12348-011-0028-8. Epub 2011 Jul 10. PubMed PMID: 21744285; PubMed Central PMCID: PMC3168374.
