TJ Hollingsworth, PhD
Assistant Professor
Department of Ophthalmology
Department of Anatomy and Neurobiology
University of Tennessee Health Science Center
Hamilton Eye Institute
930 Madison Ave, Ste 737
Memphis, TN 38163
Phone: 901.448.7830
Fax: 901.448.5028
Email: thollin1@uthsc.edu
Education
- PhD Institution: University of Alabama at Birmingham; Vision Science Graduate Program; Department of Optometry
- Postdoctoral: University of Oklahoma Health Science Center; Department of Physiology
- Postdoctoral: University of Tennessee Health Science Center; Department of Ophthalmology, Hamilton Eye Institute
Link
Research Interests
Molecular mechanisms of disease pathogenesis underlying neurodegenerative diseases of the retina including retinitis pigmentosa, Leber congenital amaurosis, age-related macular degeneration, and glaucoma; gene therapy; the role of inflammation in retinal disease pathogenesis; small molecular therapies for treating retinal disease.
Representative Publications
- Rho, J., Percelay, P., Pilkinton, S., Hollingsworth, T.J., Jablonski, M. M. An Overview of Age-Related Macular Degeneration: Clinical, Pre-Clinical Animal Models and Bidirectional Translation. Animal Models in Medicine and Biology. London, SW7 2QJ: IntechOpen 2021.
- Pilkinton, S., Hollingsworth, T.J., Jerkins, B.M., Jablonski, M.M. An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models. Animal Models in Medicine and Biology. London, SW7 2QJ: IntechOpen 2021.
- Jordan, KE, Jablonski, MM, and Hollingsworth, TJ. Inflammation in the pathogenesis of progressive retinal dystrophies. Journal of Ophthalmic Research and Vision Care. 2021.
- Hollingsworth TJ, Hubbard MG, Levi HJ, White W, Wang X, Simpson R, Jablonski MM, Gross AK. Proinflammatory Pathways Are Activated in the Human Q344X Rhodopsin Knock-In Mouse Model of Retinitis Pigmentosa. Biomolecules. 2021 Aug 6;11(8). doi: 10.3390/biom11081163. PubMed PMID: 34439829; PubMed Central PMCID: PMC8393353.
- Hussain SM, Kansal RG, Alvarez MA, Hollingsworth TJ, Elahi A, Miranda-Carboni G, Hendrick LE, Pingili AK, Albritton LM, Dickson PV, Deneve JL, Yakoub D, Hayes DN, Kurosu M, Shibata D, Makowski L, Glazer ES. Role of TGF-β in pancreatic ductal adenocarcinoma progression and PD-L1 expression.Cell Oncol (Dordr). 2021 Jun;44(3):673-687. doi: 10.1007/s13402-021-00594-0. Epub 2021 Mar 10. PubMed PMID: 33694102.
- Calame DJ, Xiao J, Khan MM, Hollingsworth TJ, Xue Y, Person AL, LeDoux MS. Presynaptic PRRT2 Deficiency Causes Cerebellar Dysfunction and Paroxysmal Kinesigenic Dyskinesia. Neuroscience.2020 Nov 10;448:272-286. doi: 10.1016/j.neuroscience.2020.08.034. Epub 2020 Sep 4. PubMed PMID: 32891704.
- Ibrahim MM, Maria DN, Wang X, Simpson RN, Hollingsworth TJ, Jablonski MM. Enhanced Corneal Penetration of a Poorly Permeable Drug Using Bioadhesive Multiple Microemulsion Technology.Pharmaceutics. 2020 Jul 26;12(8). doi: 10.3390/pharmaceutics12080704. PubMed PMID: 32722550; PubMed Central PMCID: PMC7463957.