Amy L. McGregor, M.D.

Amy L. McGregor, M.D.

Associate Professor, Department of Neurology & Pediatrics


Education

  • B.A. - Haverford College, Philadelphia, PA, 1994
  • M.D. - Washington University School of Medicine, 1998

Post-Graduate Training

  • Resident - Pediatrics, University of Texas - Houston Medical School, 2001
  • Resident - Child Neurology, University of Texas - Houston Medical School, 2004
  • Fellow Clinical Neurophysiology, University of Texas - Houston Medical School, 2005

Professional Certification and Licensing

  • Texas, 2000
  • Tennessee, 2005
  • Board Certified - American Board of Pediatrics, 2001
  • Board Certified - American Board of Psychiatry and Neurology, 2005

Research Interests

Epilepsy

Representative Publications

A. McGregor , J. Wheless. Pediatric experience with sudden unexplained death in epilepsy (SUDEP) at a tertiary epilepsy center. J Child Neurol, 2006; 21(9): 782 -787.

Y-t Ng, MD, FRACP; A.L. McGregor, MD, D.C. Duane, MD, H. Jahnke, RN, MSN, C.R. Bird, MD; and J.W. Wheless, MD. Childhood mesial temporal sclerosis. J Child Neurol. 2006 June; 21(6): 512 - 7

McGregor A , Wheless J, Baumgartner J, Bettis D. Right-sided vagus nerve stimulation as a treatment of refactory epilepsy in humans. Epilepsia 2005; 46: 91-96

E. Pataraia, MD, P.G. Simos, PhD; E.M. Castillo, PhD; R.L. Billingsley-Marshall, PhD; A.L.McGregor, MD; J.I. Breier, PhD; S Sarkari, PhD; and A.C. Papanicolaou, PhD.Reorganization of language-specific cortex in patients with lesions or mesial temporal epilepsy. Neurology 2004; 63: 1825 -1832.

Ng Y, McGregor AL, Wheless JW. Magnetic Resonance imaging detection of mesial temporal sclerosis in children. Pediatr Neurol 2004; 30: 81- 85.

Mady MA, Kossoff EH, McGregor AL, Wheless JW, Pyzik PL, Freeman JM. The ketogenic diet: adolescents can do it, too. Epilepsia 2003; 44:847 -851.

Trotter JL, Pelfrey CM, Trotter AL, Selvidge JA, Gushleff KC, Mohanakumar T, McFarland HF. T cell recognition of myelin proteolipid protein (PLP) and PLP peptides in the peripheral blood of MS and control subjects. Journal of Neuroimmunology 1998; 84:172- 8.

Trotter JL, Damico CA, Trotter AL, Collins KG, Cross AH. Interleukin-2 binding protein in sera from normal subjects and multiple sclerosis patients. Neurology 1995; 45: 197 -4.

Abstracts / Poster presentations

McGregor A , Clarke D, Brewer V, Perkins F, Wheless J. Neuropsychological and Video-EEG Findings in Children with Non-Epileptic Seizures Evaluated at a Tertiary Epilepsy Center. American Epilepsy Society Meeting December 2006.

Clarke DF, Sharp L, Perkins FF, McGregor A, Slater J, Waller A, Wheless JW, Baumgartner JE. PreOp and PostOp Seizures in Patient Status Post Corpus Callosotomy. AAN Annual Meeting- Abstract- 2006

Freedom F. Perkins, Dave F. Clarke, Amy Waller, Jeremy D. Slater, Amy L. McGregor, Mark H. McManis, Eduardo M. Castillo, James W. Wheless, and James E. Baumgartner. The Corpus Callostomy Experience at the Texas Comprehensive Epilepsy Program. Epilepsia 2005; 46 Suppl 8; 257. American Epilepsy Society Meeting, December 2005

Jeremy D. Slater, Mark H. McManis, Dave Clarke, Freedom F. Perkins, Amy L. McGregor, James H. Wheless, Joshua I. Breier, Eduardo M. Castillo, and Andrew C. Papanicoulaou. Magnetic Source Localization in Patients with Idiopathic Generalized Epilepsies. Epilepsia 2005, 46 Suppl 8; 327. American Epilepsy Society Meeting December 2005.

Amy L McGregor, Dave F. Clarke, James W. Wheless, Jeremy D. Slater, Freedom F. Perkins, Amy Waller and James Baumgartner. Surgical Experience with Vagus Nerve Stimulation (VNS) at the Texas Comprehensive Epilepsy Center. Epilepsia 2005, 46 Suppl 8:250. American Epilepsy Society Meeting, December 2005.

McGregor , J. Wheless. Pediatric experience with sudden unexplained death in epilepsy at a comprehensive epilepsy center. Epilepsia 2004; 45 Suppl 7: 274. American Epilepsy Society Meeting, December 2004.

E. Pataraia, P.G. Sims, R.L. Billingsley, E.M. Castillo, A. McGregor, W. Maggio, W. Gromley, S. Sarkari, J.I. Breier, M. Fitzgerald, A.C. Papanicolaou. Language reorganization in patients with left hemishpere lesions and mesial temporal lobe epilepsy: a magnetoencephalography study. Epilepsia 2004; 45 Suppl 3:84. Platform presentation at the 6 th European Congress on Epileptology, June 2004.

McGregor A., Baumgartner J, Bettis D, Wheless, J. Right vagus nerve stimulation as treatment of refractory epilepsy in humans. Epilepsia 2003; 44 Suppl. 9:325. American Epilepsy Society Meeting, December 2003.

NG, Y, Bird R, Duane D, McGregor AL, Wheless JW. Childhood mesial temporal sclerosis. Neurology 2003; 60: A449. AAN Hawaii, March 29 - April 5, 2003. Southern Pediatric Neurology Society March 15, 2003. Awarded the Southern Pediatric Neurology JCN/Decker Prize for neuroscience research.

Ng Y, McGregor AL, Wheless JW. Magnetic resonance imaging detection of mesial temporal sclerosis in children. Epilepsia 2002; 43:76-77. American Epilepsy Society Meeting, Seattle, Washington, December 2002.

Lectures

University of Tennessee Grand Rounds, What We Do In The EMU- May 3, 2006

Memphis and Mid-South Pediatric Society, What We Do In The EMU- June 27, 2006

Cerebral Folate Deficiency: A Case Presentation - Greater Midsouth Pediatric Neurology Update - September 23, 2006

Research

NIH Grant: Childhood Absence Epilepsy Rx, PK-PD-Pharmacogentics, Sub-Investigator ($13,000,000.00) (2003 - 2008; PI -Dr. T. Glauser).

Ortho-McNeil (Protocol No. CAPSS-272). A Double-Blind Trial Comparing the Efficacy, Tolerability, and Safety of Monotherapy Topiramate Versus Pheytoin in Subjects with Seizures Indicative of New Onset Epilepsy. Sub-Investigator, (2005-2006) ($19,000.00).

Ovation (Protocol OV-1002). Safety and Efficacy of Clobazam in Subjects with Lennox-Gastaut Syndrome, Sub-Investigator, (2005 - 2006) ($95,000.00).

Ovation (Protocol OV-1004) Open-Label Extension: Safety and Efficacy of Clobazam in Subjects With Lennox-Gastaut Syndrome, Sub-Investigator, (2006) ($95,000.00).

UCB Pharma, Inc., Levetiracetam Prophylaxis Trail in Newly Diagnosed Brain Tumors, Sub-Investigator (2006 - Present) ($48,875.00).

Shainberg Neuroscience Research Fund, The Safety of Intravenous Levetiracetam, Sub-Investigator, (2006 - Present) ($48,000.00).

UCB Pharma, Inc. (Protocol NO1009) Double-Blind, A Multi-center, Randomized, Inpatient, Maximum 34 day Study of Levetiracetam Oral Solution (20-50 mg/kg) as Adjunctive Treatment of Partial Seizures, Age 1 to < 48 Months of Age, Sub-Investigator, (2006) ($169,655.00).

UCB Pharma, Inc. (Protocol NO1148) A Multi-center, Open-Label, Long-Term, Follow-up Study of the Safety and Efficacy of Levetiracetam (20-60 mg/kg/day) in Children with Partial-Onset Seizures, Sub-Investigator, (2006 - Present) ($33,935.00).

UCB Pharma, Inc. (Protocol NO1103), 19 week, Randomized, Double-Blind Safety Study to Evaluate the Cognitive and Neuropychological Effects of Levetiracetam (20-60 mg/kg/day) as Adjunctive Treatment in Children 4-16 Years Old with Partial Seizures, Sub-Investigator (2006 - Present) ($33,935.00).

King Pharmaceuticals, (Protocol K826053001), A Phase 3, Randomized, Double-Blind, Parallel, Placebo-Controlled, Multicenter Study, with Optional Open-Label Continuation, of the Efficacy and Safety of Vanquix Auto-Injector for the Management of Selected, Refractory, Patients with Epilepsy who Require Intermittent Medical Intervention to Control Episodes of Acute Repetitive Seizures, Sub-Investigator, (2006 - Present) ($40,820.00).

Shainberg Neuroscience Research Fund (Site-Sub-Investigator, Study Primary Investigator, Andrew Escayg, Ph.D., Emory University) Genetics of Epilepsy Research Study (2006 - Present).

Marinus Pharmaceuticals, (Protocol 1042-0500) A Double-Blind, Placebo-Controlled Dose Ranging Clinical Study to Evaluate the Safety, Tolerability and Antiepileptic Activity of Ganaxolone in Treatment of Patients with Infantile Spasms. Sub-Investigator, (2007 - Present) ($239,262.00).

Marinus Pharmaceuticals, (Protocol 1042-0501) An Open-Label Clinical Study to Evaluate the Safety, Tolerability, and Antiepileptic Activity of Ganaxolone in Treatment of Patients with Infantile Spasms. (Sub-Investigator) (2007 - Present).

Contact Us

Andrei V. Alexandrov, M.D.
Chairman
Department of Neurology
Semmes-Murphey Professor

Department of Neurology

855 Monroe Ave, Suite 415
Memphis, Tennessee 38163
Phone: (901) 448-6199
Fax: (901) 448-7440