Mark S. LeDoux, M.D., Ph.D.

Mark S. LeDoux, M.D., Ph.D.

Professor, Department of Neurology
Professor, Anatomy and Neurobiology

Chief, Division of Movement Disorders
Director, Dystonia and Huntington Disease Clinics
Director, Movement Disorders Research Laboratories


  • B.S. - University of Louisiana, Lafayette, 1983
  • M.D. - Louisiana State University School of Medicine, 1988
  • Ph.D. - University of Alabama at Birmingham, 1995

Post-Graduate Training

  • Fellow - Neuroanatomy/Neurophysiology, L.S.U. School of Medicine, 1985-1986
  • Intern - General Surgery, University of Alabama at Birmingham, 1988-1989
  • Resident - Neurosurgery, University of Alabama at Birmingham, 1989-1992
  • Cushing Fellow - American Association of Neurological Surgeons, 1992-1993
  • Resident - Neurology, University of Tennessee College of Medicine, 1995-1997

Professional Certification & Licensing

  • Tennessee, 1995
  • Diplomate-American Board of Psychiatry and Neurology

Clinical Subspecialty Expertise

Adult and Pediatric Movement Disorders, Botulinum Toxins for Dystonia and Spasticity, Deep Brain Stimulation

Research Interests

  • Genetics and pathobiology of primary dystonia
    • Using vertebrate and invertebrate models, human lymphoblastoid and fibroblast cell lines, and stable transfected cell lines, we study the cellular and systems biology of dystonia-associated proteins.
    • Genetic contributions to late-onset primary dystonia are being examined with whole-exome and whole genome sequencing with integrated linkage analysis and RNA-seq. We also utilize candidate gene, genome-wide association and whole-genome gene expression studies.
  • Mechanisms of neurodegeneration in Parkinson disease: several members of the tetrahydroisoquinoline (TIQ) family of monoamine alkaloids can be formed from dopamine or its oxidized metabolites and may be involved in the pathogenesis of monoaminergic cell death in Parkinson disease. To examine the potential role of TIQs in monoaminergic cell death, we have used enantiomeric-selective high-performance liquid chromatography with electrochemical detection, liquid chromatography with tandem mass spectroscopy, cell culture studies of neurotoxicity and assays of mitochondrial membrane potential.
  • Parkinson's disease- clinical phenomenology and genetics
  • Clinical trials of therapeutic interventions for movement disorders (dystonia, Huntington disease, Parkinson disease, restless legs syndrome, tardive dyskinesias)
  • Anatomy and computational organization of the motor and autonomic nervous systems
    • The neural networks mediating suprasegmental control of the blink reflex and spontaneous blinking remain poorly understood. Viral transneuronal tracing is being used to define the integrated premotor cortical and subcortical control of levator palpebrae and orbicularis oculi motoneuron activity.
    • In isolation or via interactions with striatal-thalamo-cortical pathways, olivocerebellar structures play a critical role in disorders of motor control such as ataxia and dystonia. Using neurophysiological and molecular tools, we are dissecting the relative roles of individual network elements in the positive and negative signs characteristic of individual movement disorders.

Representative Publications

To support our research efforts in the fight against Parkinson disease, dystonia and other movement disorders, give an online gift, and specify "LeDoux Laboratory."

Contact Us

Department of Neurology

855 Monroe Ave, Suite 415
Memphis, Tennessee 38163
Phone: (901) 448-6199
Fax: (901) 448-7440

Andrei V. Alexandrov, MD
Department of Neurology
Semmes-Murphey Professor

Marc Malkoff, MD
Residency Training Program Director

Paula Odom
Adult Neurology Residency
Training Coordinator
Phone: (901) 448-6661
Fax: (901) 448-7440