John N. Fain, Ph.D.
Van Vleet Professor
858 Madison Ave.
501 Molecular Science Building
Memphis, TN 38163
The research interests of my laboratory are focused on the effects of obesity and cardiovascular disease in humans on the metabolism of adipose tissue. This work is done in collaboration with Drs. Suleiman Bahouth of the Department of Pharmacology, Atul Madan of the department of surgery at the University of Miami and Harold Sacks of the Division of Endocrinology in the Department of Medicine. The hypothesis underlying this work is that the deleterious effects of obesity on hypertension, diabetes and cardiovascular disease are secondary to altered changes in adipose tissue, especially visceral fat. These changes appear to be secondary to increased inflammation in adipose tissue. It is unclear whether it is the fat cells or the non-fat cells that are more important for this process but it is changes in visceral rather than subcutaneous fat that appear to be of greater importance.
Currently we are comparing the relative release of inflammatory adipokines and the distribution of mRNAs for over 75 known proteins involved in inflammation or adipose tissue metabolism in mesenteric, omental and subcutaneous fat of morbidly obese women. A further project is comparing mRNA distribution in four to five different kinds of adipose tissue of CABG patients with cardiovascular disease as well as controls undergoing open-heart surgery for other reasons. These tissues are the epicardial fat around the coronary artery, the fat around the internal mammary artery and three types of subcutaneous adipose tissue.
- Jefferson High School, Jefferson City, Tennessee, June, 1952
- Carson-Newman College, Jefferson City, Tennessee B.S. (Magna cum laude, June, 1956)
- Emory University, Atlanta, Georgia, Ph.D. Fall, 1960 (Biochemistry)