Pharmacology Faculty Research Interests
Associate Professor - Department of Pharmacology
Research Interests: Identification of motifs in the human beta-1-adrenergic receptor that are involved in its coupling to G proteins, internalization, recycling, and resensitization after agonist exposure.
Associate Member - Department of Pharmaceutical Sciences, St. Jude
Research Interests: Clinical Pharmacology of tyrosine kinase inhibitors; Tyrosine kinase inhibitors for the treatment of childhood acute myelogenous leukemia; Pharmacokinetic variability of anticancer agents.
Assistant Member - Department of Chemical Biology and Therapeutics, St. Jude
Research Interests: Regulation of PXR and drug metabolism; regulation of PAX3-FKHR in alveolar rhabdomyosarcoma.
Professor - Department of Pharmacology
Research Interests: Control of genes regulating fat metabolism, concentrating on the control of fatty acid oxidation in liver and heart in diabetes, during fasting and in the normal, fed state.
Assistant Professor and Chair, Department of Pharmacology
Research Interests: Voltage-gated ion channels in excitable cells as relevant targets of small amphiphilic drugs and membrane lipids.
Associate Professor - Department of Pharmacology
Research Interests: Regulation of hepatic lipid/lipoprotein synthesis and secretion by insulin in obesity and type II diabetes; Regulation of Sterol-Regulatory-Element Binding Protein-1c (SREBP-1c) transcription by insulin, cyclic-AMP, and polyunsaturated fatty acids.
Professor - Department of Pharmacology
Research Interests: Cellular and molecular mechanisms of neurohumoral interactions involved in vascular smooth muscle cell hyperplasia and hypertrophy and hypertension.
Associate Professor - Department of Pharmacology
Research Interests: Mechanisms by which hormones regulate gene expression in diabetes, hyperthyroidism and obesity.
Professor - Department of Pharmacology
Research Interests: Mechanisms of transcriptional and post-transcriptional regulation of homeobox genes Msx1/3.
Assistant Professor - Department of Pharmacology
Research Interests: Current projects focus on studying the roles of activity-dependent expression of BONF (Brain Derived Neurotrophic Factor) in depression and anxiety, using molecular and biochemical, electrophysiologyical, and behavioral techniques with genetically modified mice.
Professor and Chair - Department of Pharmacology
Research Interests: Nicotine self-administration-induced plasticity in stress-reponsive brain systems: involvement of genes, neurotransmitters, and hormones.
Associate Member - Department of Pharmaceutical Sciences, St. Jude
Research Interests: Role of solute carriers in renal and hepatic anticancer drug clearance; Genetic factors contributing to interindividual variability in anticancer drug disposition.
Associate Professor - Department of Pharmacology
Research Interests: Neural mechanisms of drug addiction.
Associate Member - Department of Pharmaceutical Sciences
Research Interests: Use of preclinical models that study the pharmacokinetics and pharmacodnamics of novel anticancer drugs to enhance the design of clinical trials in children with cancer.
Associate Professor - Department of Pharmacology
Research Interests: Regulation of mammalian DNA topoisomerase IIa gene expression and the role of topo IIa in G2/M cell cycle arrest.
Assistant Professor - Department of Pharmacology
Research Interests: Neurobiological mechanisms underlying drug addiction.
Associate Professor - Department of Pharmacology
Research Interests: Preclinical development of novel antitumor agents
Assistant Professor - Department of Pharmacology
Research Interests: Regulation of synaptic transmission and neuronal excitability by localized signaling systems.
Assistant Professor - Department of Pharmacology
Research Interests: Dopamine and serotonin systems in the brain and their involvement in neuropsychiatric disorders.