Research Interests: Identification of motifs in the human beta-1-adrenergic receptor that are involved in its coupling to G proteins, internalization, recycling, and resensitization after agonist exposure.

Research Interests: Clinical Pharmacology of tyrosine kinase inhibitors; Tyrosine kinase inhibitors for the treatment of childhood acute myelogenous leukemia; Pharmacokinetic variability of anticancer agents.

Research Interests: Regulation of PXR and drug metabolism; regulation of PAX3-FKHR in alveolar rhabdomyosarcoma.

Research Interests: Control of genes regulating fat metabolism, concentrating on the control of fatty acid oxidation in liver and heart in diabetes, during fasting and in the normal, fed state.

Research Interests: Voltage-gated ion channels in excitable cells as relevant targets of small amphiphilic drugs and membrane lipids.

Research Interests: Regulation of hepatic lipid/lipoprotein synthesis and secretion by insulin in obesity and type II diabetes; Regulation of Sterol-Regulatory-Element Binding Protein-1c (SREBP-1c) transcription by insulin, cyclic-AMP, and polyunsaturated fatty acids.

Research Interests: Cellular and molecular mechanisms of neurohumoral interactions involved in vascular smooth muscle cell hyperplasia and hypertrophy and hypertension.

Research Interests: Investigation of how cells “pre-arrange” multiple signaling components in G protein-coupled receptor signal transduction cascades with focus on caveolae and lipid rafts as centers for such organization.

Research Interests: Mechanisms by which hormones regulate gene expression in diabetes, hyperthyroidism and obesity.

Research Interests: Hematopoietic stem cell biology and gene therapy for hemoglobin disorders.

Research Interests: Mechanisms of transcriptional and post-transcriptional regulation of homeobox genes Msx1/3.

Research Interests: Current projects focus on studying the roles of activity-dependent expression of BONF (Brain Derived Neurotrophic Factor) in depression and anxiety, using molecular and biochemical, electrophysiologyical, and behavioral techniques with genetically modified mice.

Research Interests: Nicotine self-administration-induced plasticity in stress-reponsive brain systems: involvement of genes, neurotransmitters, and hormones.

Research Interests: Role of solute carriers in renal and hepatic anticancer drug clearance; Genetic factors contributing to interindividual variability in anticancer drug disposition.

Research Interests: Neural mechanisms of drug addiction.

Research Interests: Use of preclinical models that study the pharmacokinetics and pharmacodnamics of novel anticancer drugs to enhance the design of clinical trials in children with cancer.

Research Interests: Regulation of mammalian DNA topoisomerase IIa gene expression and the role of topo IIa in G2/M cell cycle arrest.

Research Interests: Neurobiological mechanisms underlying drug addiction.

Research Interests: Preclinical development of novel antitumor agents

Research Interests: Regulation of synaptic transmission and neuronal excitability by localized signaling systems.

Research Interests: Cancer and antiviral drug discovery using computational chemistry and high-throughput medicinal chemistry.

Research Interests: Dopamine and serotonin systems in the brain and their involvement in neuropsychiatric disorders.