Research Interests: Understanding the neurophysiological properties of neurosecretory neurons and their relationship to hormone secretion.

Research Interests: Neurobiology and behavior genetics of sensory systems.

Research Interests: Calcium imaging and electrophysiology in brain slices; Dendritic integration and intrinsic membrane properties responsible for firing patterns of dopaminergic neurons in the basal ganglia.

Research Interests: Role of ion channel dysfunction in Huntington's disease and Alzheimer's disease.

Research Interests: Development and application of gene therapy for treating developmental and degenerative retinal diseases; growth, aging, and injury responses of the retina to oxidative stress; Internet-based, automated, diagnostic methods for blinding eye diseases; application of electrochemical sensors to clinical medicine and surgery; ocular surgical instrument design based on nonafabrication techniques.

Research Interests: Metabolism disorders that affect organs, the central, peripheral and enteric nervous system in children and mouse models. Further interest is on striated muscle development and the involvement of a muscle-specific ubiquitin ligase in human myopathies.

Research Interests: Cell cycle exit mechanisms, upstream regulators, evolution and neural progenitor cell proliferation, and computational model of retinal development.

Research Interests: Fetal alcohol effects in brain development of normal and mutant rodents; Corpus callosum and neocortex in sensory systems development.

Research Interests: Neuroanatomy, neurophysiology and neurochemistry of brain circuits involved in pain/analgesia, taste and olfaction at the molecular, cellular, systems and behavioral levels.

Research Interests: Neural regulation of choroidal blood flow and the importance of this regulation for the health of the eye. The particular area of concentration is how this regulation is altered in disease as well as in the normal aging process.

Research Interests: My research focuses on understanding the basic principles of neural encoding of sensory information and how both experience and learning can affect this process. Specifically, my work has focused on investigating how simple forms of learning can enhance sensory processing in the early stages of the olfactory pathway and lead to changes in perception.

Research Interests: Roles of ion channels in determining neuronal integrative properties; Diversity of Ca2+ and K+ channels; Modulation of ionic currents and neuronal firing behavior by transmitters (e.g. norepinephrine, serotonin, acetylcholine,dopamine); Postnatal development of neuronal integrative behavior.

Research Interests: Response of the retina to injury; Selective killing of brain cancer cells.

Research Interests: Interaction of the mouse genotype with the effects of ethanol on the severity of ethanol-induced deficits following in utero alcohol and the response of the animal to adult ethanol exposure.

Research Interests: Structure and function of the cerebellar cortical network, cerebrocerebellar interaction, neuronal mechanisms of motor control, dynamics of neuronal communication during behavior.

Research Interests: Our lab's primary research interest is in understanding the neural mechanisms mediating fear and anxiety in the mammalian brain, with special emphasis focused on GABAergic mechanisms and influences.

Research Interests: Sensory neuron specification and axonal pathfinding in the developing chick embryo.

Research Interests: Retinal development and degeneration; Regulation of photoreceptor outer segments assembly; Identification of mouse models of ocular abnormalities.

Research Interests: Physiology and anatomy of the basal ganglia.

Research Interests: Eyelid sensorimotor and ocular autonomic networks; Molecular biology of adaptive and maladaptive sensorimotor plasticity; Mechanisms of cell death in Parkinson's disease.

Research Interests: The relationship between viruses, especially HTLV-1, and immune-associated diseases of the human central nervous system, particularly multiple sclerosis (MS).

Research Interests: Neurobiology: Molecular and cellular mechainsms underlying Abeta-induced synaptic damage; drug target validation, pharmacology and cell signaling pathways.

Research Interests: Analysis of complex behavior and neuropathology in murine models of Alzheimer's and Parkinson's diseases. Application of novel genetic therapies targeting gangliosides, to prevent or reverse cognitive deficits and neuropathology.

Research Interests: The role of the DNA damage response in the nervous system, and how this functions to prevent disease.

Research Interests: Role of regulated gene expression in degenerative and regenerative responses in the mammalian nervous system.

Research Interests: Modulation of somatosensory responsiveness during hand movements requiring sensorimotor integration.

Research Interests: Brain injury and protection in experimental stroke.

Research Interests: Ion channel physiology; regulation of neuronal function by ion channel targeting and localization.

Research Interests: Functional neuroimaging.

Research Interests... Neurobiology of neurodegenerative disease.

Research Interests: Investigation of the functions of genes involved in human neurological disease using the powerful genetic model organism Drosophila melanogaster (fruit flies).

Research Interests: Gene therapy for retinal degenerations.

Research Interests: Current projects focus on studying the roles of activity-dependent expression of BONF (Brain Derived Neurotrophic Factor) in depression and anxiety, using molecular and biochemical, electrophysiologyical, and behavioral techniques with genetically modified mice.

Research Interests: Modulation of ion channels by neuromodulators in sensory neurons and dopamine neurons.

Research Interests: Cell biology of Parkinson's disease and effects of drugs of abuse on nervous system organization.

Research Interests: Role of sympathetic neurotransmission in diabetic retinopathy and macular degeneration and the role of cellular signaling in these diseases.

Research Interests: Neural mechanisms of drug addiction.

Research Interests: Regulation of synaptic transmission and neuronal excitability by localized signaling systems.

Research Interests: Mechanisms of synaptic transmission. Development of pediatric disease model. Identification of biologically-active compounds.

Research Interests: Reduction of the morbidity and mortality associated with neurological disease.

Research Interests: Roles of sensory experience in somatosensory cortical plasticity.

Research Interests: Systems genetics, complex trait analysis, and functional genomics. Control of gene expression. Genetics of CNS diseases and addiction. Visual system structure, function, development. Advanced methods in collaborative research and data sharing.

Research Interests: Synaptic plasticity in the hippocampus, functional organization of the auditory cortex, and mechanisms of sound perception.

Research Interests: Dopamine and serotonin systems in the brain and their involvement in neuropsychiatric disorders.

Research Interests: Hair cell regeneration and function in the mouse inner ear.