Research Interests: Normal and neoplastic growth regulation in the brain.

Research Interests: Growth control during vertebrate neural development.

Research Interests: Statistical analysis methodologies for data analyses in cell and molecular biology and genetics, particularly in genome-wide studies and genotype-phenotype association studies.

Research Interests: Angiogenesis inhibition and gene therapy for cancer treatment and hemophilia.

Research Interests: Understanding the molecular mechanisms that regulate normal hematopoiesis and determining how these pathways are altered in human leukemia.

Research Interests: Breast cancer cell biology: estrogen receptor function and regulation; gene transcription regulation during tumor progression; molecular mechanism of drug resistance.

Research Interests: Positional cloning and functional study of spontaneous mutations in mice; Identification of genetic factors that regulate bone quality and resistance to arthritis.

Research Interests: Assembly of the transcriptional activation complex by nuclear hormone receptors; development of novel therapeutic agents for pediatric orphan diseases.

Research Interests: Biochemical pathways in cytokine receptor signal transduction; Roles of the Jak family of kinases and the Stat family of transcription factors.

Research Interests: Structural studies of tumor suppressor proteins.

Research Interests: Autophagy and mitochondrial clearance: regulation, signaling pathways, role in red blood cell maturation and suppression of tumors.

Research Interests: Yeast and cell culture model systems to study biochemical mechanisms of epigenetic and chromatin-based gene regulation that are deregulated in cancer.

Research Interests: NK cell and stem cell transplantation; late effect and molecular epidemiology.

Research Interests: Development of novel antitumor agents, PKC-mediated apoptotic signalling, circumvention of cellular drug resistance, development of dual antitumor/cardioprotective compounds.

Research Interests: Gene therapy for prostate cancer and breast cancer; mechanism study of p16-mediated inhibition of VEGF-signaling pathway and tumor metastasis; characterization of novel apoptosis-inducing gene, and development of anti-cancer drugs.

Research Interests: Directed differentiation of pluripotent stem cells and hematopoietic stem cell development and specification.

Research Interests: Genotoxic stress in the nervous system and the links to brain tumors and neurodegeneration.

Research Interests: Development and application of bioinformatics and biotechnology methodology.

Research Interests: Metabolic regulation of apoptosis; Calcium homeostasis during apoptosis, Metabolic regulation of ER stress.

Research Interests: Hedgehog signaling in development and disease.

Research Interests: Role of homeobox genes in early mammalian development

Research Interests: Regulation of anti-apoptotic MCL-1 during hematopoietic development and function.

Research Interests: Contribution of the RNAi pathway in promoting genomic stability by establishing and propagating centromeric heterochromatin.

Research Interests: Interferons and cytokines: receptor structure, transmembrane signaling, regulation of gene expression and mechanism of anticancer action.

Research Interests: Pharmacogenetics of antileukemic agents; Drug-induced cancers.

Research Interests: Role of cyclin-dependent kinase inhibitory proteins and tumor suppressors in cell proliferation and cancer.

Research Interests: Gene therapy for hematopoietic disorders; Biology of hematopoietic stem cells and ABC transporters.

Research Interests: Role of ABC transporters in response to chemotherapy, Biological function of ABC transporters and Regulation of ABC transporters

Research Interests: Breast cancer, metastasis, hypoxia-induced gene expression profiling, role of hypoxia in tumor initiating cells (cancer stem cells); the role of VHL in renal clear cell carcinoma; using transgenic mice as pre-clinical models for novel therapeutic testing.

Research Interests: Neuroendocrinology of the skin.

Research Interests: Molecular mechanisms of mammalian pancreas development.

Research Interests: Gene therapy of Wiskott-Aldrich Syndrome, an x-linked immunodeficiency and thrombocytopenia, using retroviral vectors to gene correct the syndrome in a mouse model.

Research Interests: DNA damage responses and gene transcription: NF-kB signaling, genotoxic stress signal transduction, apoptosis and gene regulation in cancer development.

Research Interests: Genetic basis of racial differences in response to antileukemic agents; molecular mechanisms of drug resistance; pharmacogenomics of novel agents.

Research Interests: Characterization of the p53 tumor suppressor signaling pathway.