Division Faculty: Toan D. Nguyen, M.D.

Toan D. Nguyen, M.D.

Chief of the Medical Service, VA


Medical School

University of Chicago (1978)


University of Chicago Hospitals and Clinics


Clinical & Research Gastroenterology, Stanford University

Board Certification

American Board of Internal Medicine
American Board of Internal Medicine, Gastroenterology

Clinical Interest

General Gastroenterology
Pancreatic Diseases

Research Interest

Pathophysiology of intestinal and pancreatic cellular transport.

Selected Publications

  1. Nguyen, T.D., Koh, D.-S., Moody, M.W., Fox, N.R., Savard, C., Kuver, R., Hille, B., and Lee, S.P. Characterization of two distinct chloride channels in cultured dog pancreatic duct epithelial cells. Am. J. Physiol. 272: G172-180, 1997.
  2. Nguyen, T.D., Okolo, C., and Moody, M.W.: Histamine stimulates secretion by non-transformed pancreatic duct epithelial cells. Am. J. Physiol., 275: G76-84, 1998.
  3. Nguyen, T.D., Moody , M.W., Savard, C.E., and Lee, S.P. Secretory effects of ATP on non-transformed dog pancreatic duct epithelial cells. Am. J. Physiol., 275: G104-113, 1998.
  4. Oda, D., Savard, C.E., Nguyen, T.D., Swenson, E.R., and Lee, S.P. Culture of human main pancreatic duct epithelial cells. In Vitro Cell Dev. Biol., 34: 211-216, 1998.
  5. Nguyen, T.D., Moody, M.W., Steinhoff, M., Okolo, C., Koh, D.-S., and Bunnett, N.W. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J. Clin. Invest. 103: 261-269, 1999.
  6. Koh, D.-S., Moody, M.W., Nguyen, T.D., and Hille, B. Regulation of exocytosis by protein kinases and Ca2+ in pancreatic duct epithelial cells. J. Gen. Physiol. 116:507-520, 2000.
  7. Nguyen, T.D., Meichle, S., Kim, U.-S., Wong, T., and Moody, M.W. P2Y11, a purinergic receptor acting via cAMP, mediates secretion by pancreatic duct epithelial cells. Am. J. Physiol. 280: G795-G804, 2001.
  8. Chen, E.Y., and Nguyen, T.D. Image in Medicine: Gallbladder sludge. N. Engl. J. Med. 345: e2, 2001.
  9. Okolo, C.N., Wong, T., Moody, M.W., and Nguyen, T.D. Effects of bile acids on dog pancreatic duct epithelial cell secretion and monolayer resistance. Am. J. Physiol. 283: G1042-G1050, 2002.
  10. Ko, C.W., Dominitz, J.D., and Nguyen, T.D. Fecal occult blood testing in a general medical clinic: Comparison between guaiac-based and immunochemical tests. Am. J. Med. 15: 111-114, 2003.
  11. Nguyen, T.D. Proteinase activated receptor 2: A protean effector comes of age (Editorial). Gastroenterology 126: 1907-1909, 2004.
  12. Nguyen, T.D., Kim, U.-S., and Perrine, S.P. Novel short chain fatty acids restore chloride secretion in cystic fibrosis. Biochem. Biophys. Res. Comm. 342: 245-252, 2006.
  13. Jung, S.-R., Nguyen, T.D., Hille, B., and Koh, D.-S. The pattern of intracellular Ca¬2+ signal matters in epithelial secretion. Physiol. News 69: 25-27, 2007.
  14. Kim, M.-H., Choi, B.-H., Jung, S.-R., Sernka, T.J., Kim, S.H., Kim, K.-T., Hille, B., Nguyen, T.D., and Koh, D.-S. Proteinase-activated receptor-2 increases exocytosis and mucin secretion via multiple signal transduction pathways in pancreatic duct epithelial cells. J. Biol. Chem. 283: 18711-18720, 2008.
  15. Jung, S-R, Hille, B., Nguyen, T.D., and Koh, D.S. Cyclic AMP potentiates Ca2+-dependent exocytosis in pancreatic duct epithelial cells. J. Gen. Physiol. In Press 2010.

Selected Book Chapter

  1. Nguyen, T.D. Vasoactive Intestinal Peptide. In Encyclopedia of Gastroenterology, L. R. Johnson Ed. Academic Press. San Diego, CA. 2004..
  2. Nguyen, T.D., Wong, T., Savard, C., Lee, S.P. Monolayer cultures of dog pancreatic duct cells as a model for pancreatic duct function. In Pancreapedia, J. Williams, Ed., On Line, 2011.
Gastro instrument endoscope

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Division of Gastroenterology and Hepatology
956 Court Ave, Suite H314
Memphis, TN 38163
Phone: 901-448-2510
Fax: 901-448-7836
Site contact: Donna Heath

A division of the
Department of Internal Medicine