Division Faculty: Charles M. Mansbach, II, M.D.

Charles M. Mansbach, II, M.D.

Professor of Medicine and Physiology



The Mansbach Laboratory

Medical School

New York University, New York, NY, 1963


Duke University, Durham, NC


Gastroenterology, Duke University, Durham, NC

Board Certifications

American Board of Internal Medicine
American Board of Internal Medicine, Gastroenterology

Clinical Interests

Diarrhea and Malabsorption

Research Interests

Lipid metabolism and intracellular transport of triglycerides through intestinal absorptive cells.

Selected Publications

  1. Intestinal caveolin-1 is important for dietary fatty acid absorption. Siddiqi S, Sheth A, Patel F, Barnes M, Mansbach CM 2nd. Biochim Biophys Acta. 2013 Aug;1831(8):1311-21. doi: 10.1016/j.bbalip.2013.05.001. Epub 2013 May 7.PMID:3665238 [PubMed - in process]
  2. Phosphorylation of Sar1b releases the liver fatty acid binding protein from a multi-protein complex in intestinal cytosol enabling it to bind to the ER and bud the Pre-chylomicron transport vesicle. Siddiqi S, Mansbach CM 2nd. J Biol Chem. 2012; 287: 10178-10188. PMID: 22303004
  3. Siddiqi S, Saleem U, Abumrad NA, Davidson NO, Storch J, Siddiqi SA, Mansbach CM. A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER. J Lipid Res. 2010;51:1918-28.
  4. Mansbach CM 2nd, Siddiqi SA. The biogenesis of chylomicrons. Annu Rev Physiol. 2010;72:315-33.
  5. Siddiqi S, Siddiqi SA, Mansbach CM 2nd. Sec24C is required for docking the prechylomicron transport vesicle with the Golgi. J Lipid Res. 2010; 51:1093-100.
  6. Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem. 2009;284:7518-32.
  7. Paulus BM, Ali S, Zia AA, Munir A, Davis RC Jr, Mansbach CM, Smith WC, Weber KT. Causes and consequences of systemic venous hypertension. Am J Med Sci. 2008; 36:489-97.
  8. Siddiqi SA, Mansbach CM 2nd. PKC zeta-mediated phosphorylation controls budding of the pre-chylomicron transport vesicle. J Cell Sci. 2008;121:2327-38.
  9. Neeli, I, Siddiqi, S.A., Siddiqi, S., Lagakos, W.S., Binas, B. Gheyi, T. Storch, J, Mansbach, C.M., II. Liver fatty acid binding protein initiates budding of pre-chylomicron transport vesicles from intestinal endoplasmic reticulum. J Biol Chem 282:17974-84, 2007.
  10. Mansbach CM 2nd, Gorelick F. Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis intracellular packaging and secretion of chylomicrons. Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4): G645-50.
  11. Lu, S., Yao, Y., Cheng, X,, Mitchell, S., Meng, S., Gallagher, J.W., Shelness, G.S., Morris, G.S., Mahan, J., Frase, S., Mansbach, C.M., II, Weinberg, R.B., Black, D.D. Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. J Biol Chem 281(6):3473-4383, 2006.
  12. Siddiqi, S.A., Mahan, J., Siddiqi, S., Gorelick, F.S., and Mansbach, Charles M., II. Vesicle associated membrane Protein7 is expressed in intestinal ER. J Cell Sci 119 (Pt. 5):943-950, 2006.
  13. Maroney, S.A., Cunningham, A.C., Ferrel, J., Hu, R., Haberichter, S., Mansbach, C.M., Brodsky, R.A., Dietzen, D.J., Mast, A.E. A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression. J Thrombosis Haemostasis 4; 1114 - 1124, 2006.
  14. Siddiqi, S.A., Siddiqi, S., Mahan, J., Peggs, K., Gorelick, F.S., and Mansbach, C.M., II. The Identification of a novel ER to Golgi SNARE complex used by the Pre-chylomicron Transport Vesicle. J Biol Chem 281: 20974-20982, 2006.
  15. Siddiqi, S.A., Gorelick, F.S., Mahan, J., and Mansbach, C.M.: 2003. COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre chylomicron transport vesicle. J Cell Sci 116:415-427.
  16. Washington, L., Cook, G.A., and Mansbach, C.M. II: 2003. Inhibition of carnitine palmitoyltransferase-I in the rat small intestine inhibits export of triacylglycerol to the lymph. J. Lipid Res. 44:1395-1403.
  17. Nutting DF, Kumar NS, Siddiqi SA, Mansbach CM 2nd. Nutrient adsorption. Curr Opin Gastroenterol. 2002 Mar; 18(2): 168-75.

Gastro instrument endoscope

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Division of Gastroenterology
956 Court Ave, Suite H314
Memphis, TN 38163
Phone: 901-448-2510
Fax: 901-448-7836
Site contact: Donna Heath

A division of the
Department of Internal Medicine