Support Protocol 4: Visual Assessment of Arthritis Severity

  1. Hold the mouse (or rat) in a position that allows examination of the paws.
  2. Examine each paw from the ankle through the digits and assign pathology score of 0 to 4 according to Table 15.5.3.
    Table 15.5.3 Visual Scoring System for Evaluating Severity in Cia Rodent Models
    Severity Score Gross
    0 No evidence of erythema and swelling
    1 Erythema and mild swelling confined to the mid-foot (tarsals) or ankle joint
    2 Erythema and mild swelling extending from the ankle to the mid-foot
    3 Erythema and moderate swelling extending from the ankle to the metatarsal joints
    4 Erythema and severe swelling encompass the ankle, foot, and digits
  3. Repeat scoring of paws two to three times a week.

Avoid excessive handling of the animals, as this can reduce the severity or incidence of arthritis.

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Arnold Postlethwaite, Director
Phone: 901-448-4979

Principal Investigators:

David Brand, PhD
Monica L. Brown, DO
Hongbo Chi, PhD
Weikuan Gu, PhD
Karen Hasty, PhD
Andrew H. Kang, MD
Linda K. Myers, MD
Eugene Pinkhassik, PhD
Arnold Postlethwaite, MD
Edward Rosloniec, PhD
Andrzej Slominski, MD, PhD
John Stuart, MD
Ae-Kyeung Yi, PhD