Xenograft Core Facility

mouse

The Xenograft Core is a specialized research facility that provides a variety of advanced xenograft services to academic and industry investigators at competitive pricing. The facility is located in the Center for Cancer Research at the University of Tennessee Health Science Center in Memphis, Tennessee. 

Xenograft Core Brochure

Core Capabilities

  • A state-of-the-art vivarium with the capacity to hold 23,000 rodents
  • Studies conducted in NOD/SCID/Gamma (NSG) immunocompromised mice
  • Highly skilled scientists with decades of academic and industry oncology and drug discovery experiences who will extend their services to design experiments and to interpret data

Nanostring nCounter
The Nanostring nCounter analysis system is highly sensitive technology used to measure differential gene expression in either formalin-fixed or fresh frozen tissues.

QTRSP 4000
LC/MS/MS (QTRAP 4000) is used to quantify drugs in various matrices in pharmacokinetic and pharmacodynamic xenograft studies.

IVIS Lumina bio-imager
When tumor cells are labeled with either a fluorophore or a luciferase-based reporter, the IVIS Lumina bio-imager is used to measure primary tumor growth and visualize sites of metastasis in live animals.

Other Services

  • Fluorescent or luminescent labeling of cells
  • Data analysis and bioinformatic support 
  • Whole genome sequencing through the UTHSC Molecular Resource Center
  • Integrated histology services
  • Access to patient-derived xenograft (PDX) models for validation
Cancer Research Building

Contact Us

Xenograft Core Facility

Lawrence Pfeffer, PhD
Room 154
Cancer Research Building
The University of Tennessee Health Science Center
(901) 448-7855
xenograftcore@uthsc.edu